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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 123 - 128 (6page)
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초록· 키워드
오류제보하기
Demineralized dentin matrix (DDM) has been used as a recombinant human bone morphogenetic protein-2 (rhBMP-2) carrier in many clinical trials. To optimize the clinical safety and efficacy of rhBMP-2 with DDM, efforts have been made to improve the delivery of rhBMP-2 by 1) lowering the administered dose, 2) localizing the protein, and 3) prolonging its retention time at the action site as well as the bone forming capacity of the carrier itself. The release profile of rhBMP-2 that is associated with endogenous BMP in dentin has been postulated according to the type of incorporation, which is attributed to the loosened interfibrillar space and nanoporous dentinal tubule pores. Physically adsorbed and modified, physically entrapped rhBMP-2 is sequentially released from the DDM surface during the early stage of implantation. As DDM degradation progresses, the loosened interfibrillar space and enlarged dentinal tubules release the entrapped rhBMP-2. Finally, the endogenous BMP in dentin is released with osteoclastic dentin resorption. According to the postulated release profile, DDM can therefore be used in a controlled manner as a sequential delivery scaffold for rhBMP-2, thus sustaining the rhBMP-2 concentration for a prolonged period due to localization. In addition, we attempted to determine how to lower the rhBMP-2 concentration to 0.2 mg/mL, which is lower than the approved 1.5 mg/mL.
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등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Urist MR / 1965 / Bone : formation by autoinduction / Science 150:893~899
Urist MR / 1968 / Inductive substrates for bone formation / Clin Orthop Relat Res 59:59~96
Wozney JM / 1988 / Novel regulators of bone formation : molecular clones and activities / Science 242:1528~1534
Reddi AH / 1998 / Role of morphogenetic proteins in skeletal tissue engineering and regeneration / Nat Biotechnol 16:247~252
Boyne PJ / 1980 / Grafting of the maxillary sinus floor with autogenous marrow and bone / J Oral Surg 38:613~616
Urist MR / 1968 / Inductive substrates for bone formation / Clin Orthop Relat Res 59:59~96
Wozney JM / 1988 / Novel regulators of bone formation : molecular clones and activities / Science 242:1528~1534
Reddi AH / 1998 / Role of morphogenetic proteins in skeletal tissue engineering and regeneration / Nat Biotechnol 16:247~252
Boyne PJ / 1980 / Grafting of the maxillary sinus floor with autogenous marrow and bone / J Oral Surg 38:613~616
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