지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 86 - 92 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaFamily and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population.
MethodsaaIn this age- and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD.
ResultsaaNo significant differences were evident in the allele frequencies or genotype distributions of the COMT (rs4680), 5-HTTLPR polymorphisms or the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients and controls. Although there were no significant associations of these polymorphisms with in subgroups of PD patients differentiated by gender or in subgroup comorbid with agoraphobia (AP), significant difference was observed in genotype distributions of the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients without AP and controls (p=0.047).
ConclusionaaIn this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Kaplan HI / 1994 / Kaplan and Sadock’s Synopsis of Psychiatry: Behavioral Sciences, Clinical Psychiatry / Williams & Wilkins
Kessler RC / 2006 / The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication / Arch Gen Psychiatry 63:415~424
Carlbring P / 2002 / 12-month prevalence of panic disorder with or without agoraphobia in the Swedish general population / Soc Psychiatry Psychiatr Epidemiol 37:207~211
Crowe RR / 1983 / A family study of panic disorder / Arch Gen Psychiatry 40:1065~1069
Harris EL / 1983 / Family study of agoraphobia. Report of a pilot study / Arch Gen Psychiatry 40:1061~1064
Kessler RC / 2006 / The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication / Arch Gen Psychiatry 63:415~424
Carlbring P / 2002 / 12-month prevalence of panic disorder with or without agoraphobia in the Swedish general population / Soc Psychiatry Psychiatr Epidemiol 37:207~211
Crowe RR / 1983 / A family study of panic disorder / Arch Gen Psychiatry 40:1065~1069
Harris EL / 1983 / Family study of agoraphobia. Report of a pilot study / Arch Gen Psychiatry 40:1061~1064
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