Associations between Single Nucleotide Polymorphisms of COX-2 and MMP-2 Genes and Colorectal Cancer Susceptibility in the Saudi Population

Shalaby, Manal Ali; Nounou, Howaida Attia; Alanazi, Mohammad Saud; Alharby, Othman; Azzam, Nahla; Saeed, Hesham Mahmoud

추천

검색

자료유형: 학술저널

저자정보: Shalaby, Manal Ali (Genetic Engineering and Biotechnology Research Institute [GEBRI], City for Scientific Research and Technology Applications) Nounou, Howaida Attia (Department of Medical Biochemistry, Faculty of Medicine, Alexandria University) Alanazi, Mohammad Saud (Department of Biochemistry, College of Science, King Khalid University Hospital, King Saud University) Alharby, Othman (Department of Internal Medicine, Division of Gastroenterology, King Khalid University Hospital, King Saud University) Azzam, Nahla (Department of Internal Medicine, Division of Gastroenterology, King Khalid University Hospital, King Saud University) Saeed, Hesham Mahmoud (Institute of Graduate Studies and Research, Department of Bioscience and Technology, Alexandria University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제12호

발행연도: 2014.1

수록면: 4,989 - 4,994 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: It has been reported that COX-2 expression is associated with MMP-2 expression in thyroid and breast cancers, suggesting that MMPs are linked to COX-2-mediated carcinogenesis. Several polymorphisms within the MMP2 promoter region have been reported in cases with oncogenesis and tumor progression, especially in colorectal carcinogenesis. Materials and Methods: This research evaluated risk of association of the SNPs, including genes for COX-2 (AIG transition at +202) and MMP-2 (Crr transition at-1306), with colorectal cancer in 125 patients and 125 healthy controls. Results and Conclusions: Our data confirmed that MMP2 C-1306 T mutations were significantly more common in colon cancer patients than in our control Saudi population; p=O.0121. On the other hand in our study, there was no significant association between genotype distribution ofthe COX2 polymorphism and colorectal cancer; p=0.847. An elevated frequency ofthe mutated genotype in the control group as compared to the patients subjects indeed suggested that this polymorphism could decrease risk in the Saudi population. Our study confirmed that the polymorphisms that could affect the expressions of MMP-2 and COX-2 the colon cancer patients were significantly higher than that in the COX-2 negative group. The frequency of individuals with MMP2 polymorphisms in colon cancer patients was higher than individuals with combination of COX2 and MMP2 polymorphisms. Our study confirmed that individuals who carried the polymorphisms that could affect the expressions ofCOX2 are more susceptible to colon cancer. MMP2 regulatory polymorphisms could be considered as protective; further studies need to confirm the results with more samples and healthy subjects.

#Colorectal cancer #single nucleotide polymorphism #matrix metalloproteinase #cyclooxygenase

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Shalaby, Manal Ali

소속기관 Genetic Engineering and Biotechnology Research Institute [GEBRI], City for Scientific Research and T