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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 393 - 408 (16page)
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초록· 키워드
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Statement of problem. In the process of bone formation, titanium (Ti) surface roughness is an important factor modulating osteoblastic function. Purpose. This study was carried out to determine the effect of different Ti surface on biologic responses of a human osteoblast-like cell line (MG63). Materials and methods. MG63 cells were cultured on S (smooth), SLA (sandblasted largegrit & acid etching), HA (hydroxyapatite) Ti. The morphology and attachment of the cells were examined by SEM. The cDNAs prepared from total RNAs of MG63 were hybridized to a human cDNA microarray (1,152 elements). Results. The appearances of the surfaces observed with SEM were different in the three types of dental substrates. The surface of SLA and HA were shown to be rougher than S. MG63 cells cultured on SLA and HA were cell-matrix interaction. In the expression of genes involved in osseointegration, upregulated genes were bone morphogenetic protein, Villin, Integrin, Insulin-like growth factors in different surfaces. Downregulated genes were fibroblast growth factor receptor 4, Bcl 2-related protein, collagen, CD4 in different surfaces. Conclusion. The attachment and expression of key osteogenic regulatory genes were enhanced by surface roughness of the dental materials.
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참고문헌 (26)
참고문헌 신청
/ 1996 / Use of acDNA microarray to analyse gene expression pat-terns in human cancer 14 : 457 ~ 60
/ 1998 / Cluster analysis and display of genome-wide ex-pression patterns 95 : 14863 ~ 8
/ 1999 / High-res-olution morphometric analysis of human os-teoblastic cell adhesion on clinically relevant or-thopedic alloys 24 : 499 ~ 506
/ 1999 / Interface shear strengthof titanium implants with a sandblasted andacidetched surface:a biomechanical study in themaxilla of miniature pigs 45 : 75 ~ 83
/ 1999 / Surface rough-ness modulates the response of MG 63 osteoblast-like cells to 1 Journal of Biomedical MaterialsResearch 1999 37 : 139 ~ 51
/ 1998 / Cluster analysis and display of genome-wide ex-pression patterns 95 : 14863 ~ 8
/ 1999 / High-res-olution morphometric analysis of human os-teoblastic cell adhesion on clinically relevant or-thopedic alloys 24 : 499 ~ 506
/ 1999 / Interface shear strengthof titanium implants with a sandblasted andacidetched surface:a biomechanical study in themaxilla of miniature pigs 45 : 75 ~ 83
/ 1999 / Surface rough-ness modulates the response of MG 63 osteoblast-like cells to 1 Journal of Biomedical MaterialsResearch 1999 37 : 139 ~ 51
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