지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제4호
- 발행연도
- 2017.1
- 수록면
- 391 - 401 (11page)
이용수
초록· 키워드
오류제보하기
Objective: The purpose of this study was to compare the efficacy and safety of escitalopram, paroxetine and venlafaxine in Korean patients with major depressive disorder (MDD). Methods: A total of 449 Korean MDD patients were recruited in a six-week, randomized, rater-blinded, active-controlled trial and were evenly randomized to paroxetine, venlafaxine, or escitalopram treatment. Results: When comparing the mean difference for the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating Scale (HDRS) total scores during six weeks, paroxetine (−6.4±0.4, and −5.4±0.4, respectively) was found to be significantly superior to escitalopram (−3.7±0.5 and −3.1±0.4, respectively). Venlafaxine had a significantly lower MADRS total score (−5.4±0.4) than escitalopram. When adjusting baseline variables, the response, according to the MADRS and HDRS scores, in the paroxetine group was greater than that for the escitalopram group (odds ratio [OR]=2.43, 95% confidence interval [CI]=1.42-4.16 for MADRS; and OR=2.32, 95% CI=1.35-3.97 for HDRS) and the venlafaxine group (OR=1.94, 95% CI=1.17-3.21 for MADRS; and OR=1.71, 95% CI=1.03-2.83 for HDRS). Despite that the overall tolerability was high and similar among the three groups, a total of 268 subjects (59.7%) prematurely discontinued treatment, representing the main limitation of the present study. Conclusion: Although a low study completion rate limits generalizability, our findings suggest that paroxetine might be superior to escitalopram in Korean MDD patients. Further studies should be conducted to draw a definite conclusion
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Alegria M / 2004 / Considering context, place and culture: the National Latino and Asian American Study / Int J Methods Psychiatr Res 13 : 208 ~ 220
Alonso J / 2004 / Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project / Acta Psychiatr Scand Su
Cho MJ / 1998 / Use of the Center for Epidemiologic Studies Depression(CES-D)scale in Korea / J Nerv Ment Dis 186 : 304 ~ 310
Darmansjah I / 1992 / Dose-response variation among different populations / Clin Pharmacol Ther 52 : 449 ~ 452
Ferrari AJ / 2013 / Global variation in the prevalence and incidence of major depressive disorder : a systematic review of the epidemiological literature / Psychol Med 43 : 4
Alonso J / 2004 / Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project / Acta Psychiatr Scand Su
Cho MJ / 1998 / Use of the Center for Epidemiologic Studies Depression(CES-D)scale in Korea / J Nerv Ment Dis 186 : 304 ~ 310
Darmansjah I / 1992 / Dose-response variation among different populations / Clin Pharmacol Ther 52 : 449 ~ 452
Ferrari AJ / 2013 / Global variation in the prevalence and incidence of major depressive disorder : a systematic review of the epidemiological literature / Psychol Med 43 : 4
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Escitalopram on Anxiety in Patients with Acute Coronary Syndrome: A Randomized Controlled Trial
Clinical Psychopharmacology and Neuroscience
2017 .01
-
Comparing the Effects of Bupropion and Escitalopram on Excessive Internet Game Play in Patients with Major Depressive Disorder
Clinical Psychopharmacology and Neuroscience
2017 .01
-
Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells
The Korean Journal of Physiology & Pharmacology
2017 .07
-
Long-Term Use of Escitalopram and a High Level of Carcinoembryonic Antigen
Korean Journal of Family Medicine
2016 .01
-
Acute Efficacy and Safety of Escitalopram Versus Desvenlafaxine and Vortioxetine in the Treatment of Depression With Cognitive Complaint: A Rater-Blinded Randomized Comparative Study
PSYCHIATRY INVESTIGATION
2022 .04
-
Escitalopram-Induced Amenorrhea and False Positive Urine Pregnancy Test
Korean Journal of Family Medicine
2017 .01
-
Associations between Serotonergic Genes and Escitalopram Treatment Responses in Patients with Depressive Disorder and Acute Coronary Syndrome: The EsDEPACS Study
PSYCHIATRY INVESTIGATION
2016 .01
-
Efficacy and Safety of Escitalopram, Desvenlafaxine, and Vortioxetine in the Acute Treatment of Anxious Depression: A Randomized Rater-blinded 6-week Clinical Trial
Clinical Psychopharmacology and Neuroscience
2023 .02
-
한국형 우울장애 약물치료 알고리듬 2017(Ⅵ) : 안정성, 부작용, 동반 신체질환을 고려한 항우울제 선택
우울조울병
2017 .01
-
Early Improvement in One Week Predicts the Treatment Response to Escitalopram in Patients with Social Anxiety Disorder: A Preliminary Study
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Evidence-Based Treatment for Depressive Disorder
PSYCHIATRY INVESTIGATION
2015 .01
-
한국형 우울장애 약물치료 알고리듬 2017(I) : 정신병적 양상이 없는 주요우울장애
우울조울병
2017 .01
-
Contemporary Issues in Depressive Disorders
PSYCHIATRY INVESTIGATION
2019 .01
-
Efficacy of Buspirone Augmentation of Escitalopram in Patients with Major Depressive Disorder with and without Atypical Features: A Randomized, 8 Week, Multicenter, Open-Label Clinical Trial
PSYCHIATRY INVESTIGATION
2020 .01
-
Diagnostic Issues of Depressive Disorders from Kraepelinian Dualism to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
PSYCHIATRY INVESTIGATION
2019 .01
-
Selective serotonin reuptake inhibitor escitalopram inhibits 5-HT3 receptor currents in NCB-20 cells
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Association between Obsessive-Compulsive Symptoms and Long-Term Cardiac Outcomes in Patients with Acute Coronary Syndrome: Effects of Depression Comorbidity and Treatment
PSYCHIATRY INVESTIGATION
2019 .01
-
Times to Discontinue Antidepressants Over 6 Months in Patients with Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2016 .01
-
후각관계증후군 환자 2 증례
생물치료정신의학
2016 .10
-
Prevalence of Depressive Disorder of Outpatients Visiting Two Primary Care Settings
예방의학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0