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논문 기본 정보

자료유형
학술저널
저자정보
Shin Cheolmin (Department of Psychiatry Korea University College of Medicine Korea University Ansan Hospital) Ko Young-Hoon (Department of Psychiatry Korea University College of Medicine Korea University Ansan Hospital) Shim Se-Hoon (Department of Psychiatry Soonchunhyang University College of Medicine Soonchunhyang University Cheo) Kim Ji Sun (Department of Psychiatry Soonchunhyang University College of Medicine Soonchunhyang University Cheo) Na Kyoung-Sae (Department of Psychiatry Gachon University College of Medicine Gil Medical Center) Hahn Sang-Woo (Department of Psychiatry Soonchunhyang University College of Medicine Soonchunhyang University Hosp) 이승환 (인제대학교)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제17권 제8호
발행연도
2020.1
수록면
796 - 803 (8page)

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Objective This study investigated the treatment response and cognitive enhancement effects of buspirone augmentation of escitalopram in patients with major depressive disorder (MDD), according to atypical feature subtypes of MDD.Methods An 8 week, randomized, parallel-controlled, open-label study was conducted. The Columbia Atypical Depression Diagnostic Scale was administered to evaluate atypical features. Patients were assigned randomly to the buspirone augmentation or non-buspirone groups. Symptom severity and cognitive function were evaluated using the 17-item Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Beck Depression Inventory, Beck Anxiety Inventory, digit span test, word fluency test, and Trail Making Tests A and B.Results A total of 89 patients were recruited. There were no significant differences in the measures between the groups; however, among the MDD patients without atypical features, the digit span and word fluency tests were improved by treatment. In the MDD patients without atypical features, the buspirone augmentation group showed a significant improvement on the digit span test compared to the non-buspirone group.Conclusion Buspirone augmentation did not demonstrate significant benefits in MDD patients; however, buspirone augmentation showed greater efficacy for the improvement of cognitive function in MDD patients without atypical features. Our study suggests that atypical features are an important factor for cognitive enhancement in buspirone augmentation treatment in patients with MDD.

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