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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제3호
- 발행연도
- 2016.1
- 수록면
- 261 - 269 (9page)
이용수
초록· 키워드
오류제보하기
Objective: We investigated the efficacy and tolerability of paliperidone extended-release (ER) tablets in patients with first-episode psychosis (n=75).
Methods: This was an 8-week, open-label, multicenter trial. The primary outcome variable was scores on the Positive and Negative Syndrome Scale (PANSS); secondary measures included the Scale for the Assessment of Negative Symptoms (SANS), the Cognitive Assessment Interview (CAI), and the Global Assessment of Functioning (GAF). To assess safety, we measured drug-related adverse events, weight, lipid-related variables, and prolactin and administered the Simpson–Angus Rating Scale (SARS), the Abnormal Involuntary Movement Scale (AIMS), the Barnes Akathisia Scale (BAS), the Arizona Sexual Experiences Scale (ASEX), and the Udvalg for Kliniske Undersogelser side effect rating scale (UKU).
Results: The administration of paliperidone ER resulted in significant improvement in the PANSS, SANS, CAI, and GAF scores (p＜0.001) over time. This improvement was evident as early as 1 week. The most frequent adverse events were akathisia, somnolence, anxiety, and sedation, which were well tolerated. Modest increases in weight and lipid profiles were also noted.
Prolactin levels were substantially increased at the endpoint in both male and female patients.
Conclusion: These results indicate that paliperidone ER is effective and is characterized by good tolerability in the treatment of positive and negative symptoms and cognitive functioning in first-episode psychosis.
목차
등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Lieberman J / 1993 / Time course and biologic correlates of treatment response in first-episode schizophrenia / Arch Gen Psychiatry 50:369~376
Robinson DG / 1999 / Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder / Am J Psychiatry 156:544~549
McEvoy JP / 2007 / Efficacy and tolerability of olanzapine, quetiapine, and risperidone in the treatment of early psychosis:a randomized, double-blind 52-week comparison / Am J Psychiatry 164:1050~1060
Walter G / 2001 / The pharmacologic treatment of the early phase of first-episode psychosis in youths / Can J Psychiatry 46:803~809
Opjordsmoen S / 2009 / Stability of medication in early psychosis:a comparison between second-generation and low-dose first-generation antipsychotics / Early Interv Psychiatry 3:58~65
Robinson DG / 1999 / Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder / Am J Psychiatry 156:544~549
McEvoy JP / 2007 / Efficacy and tolerability of olanzapine, quetiapine, and risperidone in the treatment of early psychosis:a randomized, double-blind 52-week comparison / Am J Psychiatry 164:1050~1060
Walter G / 2001 / The pharmacologic treatment of the early phase of first-episode psychosis in youths / Can J Psychiatry 46:803~809
Opjordsmoen S / 2009 / Stability of medication in early psychosis:a comparison between second-generation and low-dose first-generation antipsychotics / Early Interv Psychiatry 3:58~65
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