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논문 기본 정보

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학술저널
저자정보
Denis Pavăl (Iuliu Ha ț ieganu University of Medicine and Pharmacy) Nicoleta Gherghel-Pavăl (Romanian Association for Autoimmune Encephalitis) Octavia Oana Căpățînă (Iuliu Hațieganu University of Medicine and Pharmacy) Adina Stan (Iuliu Hațieganu University of Medicine and Pharmacy) Lajos Raduly (Iuliu Hațieganu University of Medicine and Pharmacy) Liviuța Budișan (Iuliu Hațieganu University of Medicine and Pharmacy) Ioana Valentina Micluția (Iuliu Hațieganu University of Medicine and Pharmacy)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience Vol.22 No.3
발행연도
2024.8
수록면
520 - 530 (11page)
DOI
10.9758/cpn.24.1164

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Objective: Autoimmune encephalitis (AE) remains an essential differential diagnosis in patients with first-episode psy chosis (FEP). In this study, we aimed to assess to prevalence of AE in a cohort of FEP patients. Methods: We used a phenotype-driven algorithm to detect AE in patients with FEP. Initially, we screened patients for warning signs with a low or high pre-test probability for AE, defined as “yellow” and “red flags”, respectively. In the next step, patients with red flags underwent cerebrospinal fluid analysis (including neural antibodies), while patients with yellow flags underwent tests for serum neural antibodies, electroencephalography, and brain magnetic resonance imaging. Results: We screened 78 patients with FEP and found that eight (10.3%) had at least one warning sign for AE: four (5.13%) patients had at least one red flag, while four (5.13%) had only yellow flags. Among these, two patients (2.56%) had anti-N-methyl-D-aspartate receptor encephalitis, while the remaining six (7.69%) received a primary psychiatric disorder diagnosis. Conclusion: Our study highlights the importance of considering AE in the differential diagnosis of FEP.

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