지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제1호
- 발행연도
- 2020.1
- 수록면
- 109 - 115 (7page)
이용수
초록· 키워드
오류제보하기
Objective: This study aims to investigate the possible relationship between plasma concentrations of apelin, visfatin and resistin levels of first episode psychosis patients and chronic schizophrenia patients. Methods: A total number of 29 untreated patients with first episode psychosis, 30 chronic schizophrenia and 29 randomly selected weight- and body mass index-matched healthy volunteers were included. The Diagnostic and Statistical Manual of Mental Disorders 4th edition, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression Scale were applied to the patient groups. The enzyme-linked immunosorbent assay method was used to measure plasma apelin, visfatin and resistin levels. Results: There was no difference in age, marital status, occupation, and BMI between the groups. Plasma apelin levels were significantly higher in first episode psychosis group than chronic schizophrenia and control group. There was no statistically significant difference in plasma visfatin levels between the groups: first episode psychosis group, chronic schizophrenia and control group. Plasma resistin levels were higher in both first episode psychosis group and chronic schizophrenia group than the control group. There was no statistically significant correlation between plasma apelin and resistin levels and total PANSS scores in the group of patients. Conclusion: To our knowledge, this study is the first which investigates the plasma apelin, visfatin and resistin levels in patients with first episode psychosis and chronic schizophrenia. Based on the results of this study, apelin and resistin may be related with some central nervous system pathologies, including the severity of a psychiatric disorder.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Abdullah Bolu / 2019 / Serum Levels of High Sensitivity C-reactive Protein in Drug-naïve First-episode Psychosis and Acute Exacerbation of Schizophrenia / Clinical Psychopharmacology and Neuroscience 17(2):244~249
Beumer W / 2012 / Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome / Psychoneuroendocrinology 37:1901~1911
Strous RD / 2006 / Schizophrenia, autoimmunity and immune system dysregulation : a comprehensive model updated and revisited / J Autoimmun 27:71~80
Nillni EA / 2000 / Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways / J Biol Chem 275:36124~36133
Rybakowski F / 2014 / Inverse relationship between leptin increase and improvement in depressive symptoms in anorexia nervosa / Neuro Endocrinol Lett 35:64~67
Beumer W / 2012 / Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome / Psychoneuroendocrinology 37:1901~1911
Strous RD / 2006 / Schizophrenia, autoimmunity and immune system dysregulation : a comprehensive model updated and revisited / J Autoimmun 27:71~80
Nillni EA / 2000 / Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways / J Biol Chem 275:36124~36133
Rybakowski F / 2014 / Inverse relationship between leptin increase and improvement in depressive symptoms in anorexia nervosa / Neuro Endocrinol Lett 35:64~67
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