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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 348 - 354 (7page)
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초록· 키워드
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Background: Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP) is a protein with altered glycosylation that reacts with lectin, and was recently identified as a useful non-invasive biomarker for the diagnosis of liver fibrosis in patients with hepatitis C virus infection.This study aimed to evaluate the diagnostic efficacy of WFA-M2BP for liver fibrosis in the context of hepatitis B virus (HBV). Methods: We enrolled 151 patients infected with HBV. Liver biopsy and elastography (Fibroscan) were performed during the initial visit. Fibrosis was graded according to the Knodell histologic activity index (F0–3). WFA-M2BP levels were determined with an automated immunoassay analyzer (M2BPGi, HISCL-5000, Sysmex, Japan). The diagnostic efficacy of WFA-M2BP was compared with those of various conventional or composite biomarkers, including enhanced liver fibrosis (ELF) score, Fibroscan, aspartate transaminase (AST)-toplatelet ratio index (APRI), and FIB-4, based on the area under the ROC curve (AUC) value. Results: The majority of patients were at fibrosis stages F1 and F2. The F2 and F3 AUC values for WFA-M2BP were similar to those for FIB-4, APRI, ELF, and Fibroscan, although the latter showed the best diagnostic efficacy. The diagnostic accuracy of all tested biomarkers for F2 and F3 was 60–70%. In multivariate analysis, WFA-M2BP, ELF, and platelet count significantly predicted stage ≥F2, whereas only platelet count significantly predicted F3. Conclusions: WFA-M2BP can support a diagnosis of liver fibrosis with similar diagnostic efficacy to other biomarkers, and predicted liver fibrosis stage ≥2 among patients with chronic hepatitis B.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Ge PS / 2016 / Treatment of patients with Cirrhosis / N Engl J Med 375:767~777
Rosenberg W / 2004 / Serum markers detect the presence of liver fibrosis: a cohort study / Gastroenterology 127:1704~1713
Ellis E / 2012 / Clinical evidence for the regression of liver fibrosis / J Hepatol 56:1171~1180
Ahmad W / 2011 / A brief review on molecule, genetic and imaging techniques for HCV fibrosis evaluation / Virol J 8:53~69
Castera L / 2010 / Biopsy and non-invasive methods for the diagnosis of liver fibrosis: does it take two to tango? / Gut 59:861~866
Rosenberg W / 2004 / Serum markers detect the presence of liver fibrosis: a cohort study / Gastroenterology 127:1704~1713
Ellis E / 2012 / Clinical evidence for the regression of liver fibrosis / J Hepatol 56:1171~1180
Ahmad W / 2011 / A brief review on molecule, genetic and imaging techniques for HCV fibrosis evaluation / Virol J 8:53~69
Castera L / 2010 / Biopsy and non-invasive methods for the diagnosis of liver fibrosis: does it take two to tango? / Gut 59:861~866
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