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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 331 - 337 (7page)
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초록· 키워드
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Background: Liver biopsies have been partially replaced by noninvasive methods for assessing liver fibrosis. We explored the usefulness of four novel biomarkers, enhanced liver fibrosis (ELF), glycosylation isomer of Mac-2 binding protein (M2BPGi), galectin-3, and soluble suppression of tumorigenicity 2 (sST2), in association with liver fibrosis. Methods: ELF, M2BPGi, galectin-3, and sST2 were assayed in 173 patients with chronic liver diseases. The results were analyzed according to fibrosis grade (F0/1, F2, and F3/4) by transient elastography (TE). Results: ELF, M2BPGi, galectin-3, and sST2 values differed significantly according to TE grade; ELF and M2BPGi values were higher in F2 and F3/4 than in F0/1 (P ≤0.001, all), sST2 values were higher in F3/4 than in F0/1 and F2 (P <0.05), and galectin-3 values were higher in F3/4 than in F0/1 (P =0.0036). ELF and M2BPGi showed good TE fibrosis detection performance (area under the curves [AUC], 0.841 and 0.833 for ≥F2; and 0.837 and 0.808 for ≥F3). The sensitivity and specificity for predicting TE grade F≥2 were 84.1% and 76.7% for ELF and 63.6% and 91.5% for M2BPGi. Conclusions: This is the first study to compare the liver fibrosis assessment of four novel biomarkers: ELF, M2BPGi, galectin-3, and sST2. The biomarkers varied significantly according to TE grade, and each biomarker showed a different trend. ELF and M2BPGi seem to have comparable good performance for detecting liver fibrosis.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Friedman SL / 2008 / Mechanisms of hepatic fibrogenesis / Gastroenterology 134:1655~1669
Kim JH / 2015 / Clinical application of transient elastography in patients with chronic viral hepatitis receiving antiviral treatment / Liver Int 35:1103~1115
Lok AS / 2009 / Hepatitis B: liver fibrosis and hepatocellular carcinoma / Gastroenterol Clin Biol 33:911~915
Dienstag JL / 1999 / Lamivudine as initial treatment for chronic hepatitis B in the United States / N Engl J Med 341:1256~1263
Kim SU / 2013 / Clinical application of liver stiffness measurement using transient elastography: a surgical perspective / Digestion 88:258~265
Kim JH / 2015 / Clinical application of transient elastography in patients with chronic viral hepatitis receiving antiviral treatment / Liver Int 35:1103~1115
Lok AS / 2009 / Hepatitis B: liver fibrosis and hepatocellular carcinoma / Gastroenterol Clin Biol 33:911~915
Dienstag JL / 1999 / Lamivudine as initial treatment for chronic hepatitis B in the United States / N Engl J Med 341:1256~1263
Kim SU / 2013 / Clinical application of liver stiffness measurement using transient elastography: a surgical perspective / Digestion 88:258~265
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