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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 33 - 44 (12page)
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Background/Aims: To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years). Results: A total of 170 patients with CHB were selected. During the follow-up period (median, 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA+-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA+- M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA+-M2BP level >2.14 experienced recurrence more frequently than those with a WFA+-M2BP level ≤2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA+-M2BP level ≤2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001). Conclusions: WFA+-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA+-M2BP level into tailored postoperative surveillance strategies for patients with CHB.
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참고문헌 (32)
참고문헌 신청
Yu SJ / 2016 / A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world : 2010-2016 / Clin Mol Hepatol 22:7~17
Han DH / 2014 / Lesson from 610 liver resections of hepatocellular carcinoma in a single center over 10 years / World J Surg Oncol 12:192
Imamura H / 2003 / Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy / J Hepatol 38:200~207
Poon RT / 2000 / Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma / Cancer 89:500~507
Kim SU / 2008 / Prediction of postoperative hepatic insufficiency by liver stiffness measurement(FibroScan((R)))before curative resection of hepatocellular carcinoma : a pilot study / Hepatol Int 2:471~477
Han DH / 2014 / Lesson from 610 liver resections of hepatocellular carcinoma in a single center over 10 years / World J Surg Oncol 12:192
Imamura H / 2003 / Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy / J Hepatol 38:200~207
Poon RT / 2000 / Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma / Cancer 89:500~507
Kim SU / 2008 / Prediction of postoperative hepatic insufficiency by liver stiffness measurement(FibroScan((R)))before curative resection of hepatocellular carcinoma : a pilot study / Hepatol Int 2:471~477
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