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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 430 - 437 (8page)
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초록· 키워드
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Background : Human telomerase reverse transcriptase (hTERT) is a catalytic enzyme that is required for telomerase activity (TA) and cancer progression. Telomerase inhibition or inactivation increases cellular sensitivity to UV irradiation, DNA-damaging agents, the tyrosine kinase inhibitor, imatinib, and
pharmacological inhibitors, such as BIBR1532. hTERT is associated with apoptosis. Some patients show drug-resistance during anti-cancer drug treatment and the cancer cell acquire anti-apoptotic mechanism. Therefore, we attempted to study correlation between hTERT and drug-resistance.
Methods : To study the correlation between protein level and activity of hTERT and drug-resistance, Western blotting and telomerase repeat amplification protocol (TRAP) assays were performed. To investigate whether hTERT contributes to drug resistance in tumor cells, we transiently decreased
hTERT levels using small interfering RNA (siRNA) in T24/R2 cells.
Results : hTERT knockdown increased Bax translocation into the mitochondria and cytochrome C release into the cytosol. Caspase inhibitors, especially Z-VAD-FMK, rescued this phenomenon, suggesting that the stability or expression of hTERT might be regulated by caspase activity.
Conclusions : These data suggest that hTERT might be a target molecule for drug-resistant tumor therapy. (Korean J Lab Med 2008;28:430-7)
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bodnar AG / 1998 / Extension of life-span by introduction of telomerase into normal human cells / Science 279 : 349 ~ 352
Chen Z / 2003 / Consequences of telomerase inhibition and combination treatments for the proliferation of cancer cells / Cancer Res 63 : 5917 ~ 5925
Cho HJ / 2006 / Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells / Cancer Lett 237 : 56 ~ 66
Chu G. / 1994 / Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair / J Biol Chem 269 : 787 ~ 790
Dettlaff-Pokora A / 2005 / Schlichtholz B. Telomerase activity in urine sediments as a tool for noninvasive detection of bladder cancer / Cancer Lett 222 : 83 ~ 88
Chen Z / 2003 / Consequences of telomerase inhibition and combination treatments for the proliferation of cancer cells / Cancer Res 63 : 5917 ~ 5925
Cho HJ / 2006 / Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells / Cancer Lett 237 : 56 ~ 66
Chu G. / 1994 / Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair / J Biol Chem 269 : 787 ~ 790
Dettlaff-Pokora A / 2005 / Schlichtholz B. Telomerase activity in urine sediments as a tool for noninvasive detection of bladder cancer / Cancer Lett 222 : 83 ~ 88
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Reduced Hepatotoxicity in hTERT Targeting Trans-splicing Ribozyme Mediated Cancer Gene Therapy In Vivo
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Changes of Telomerase Activity and Proliferation by Inhibition of Reverse Transcriptase Activity in Human Cancer Cell
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