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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.5
- 수록면
- 277 - 282 (6page)
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Purpose: Telomerase is expressed by most malignancies including thyroid cancer. In this study, to evaluate the telomerase activity, we determine the expression of human telomerase reverse transcriptase (hTERT) in benign and malignant thyroid tumors.
Methods: We examined the clinical data such as age, sex, and recurrence status of 100 patients that underwent thyroidectomy. Also, we reviewed the pathological data of the tissues (tumor size, lymph nodes, capsular invasion, perivascular invasion, perilymphatic invasion etc.). We checked hTERT expression by Allred scoring system using immunohistochemical staining.
Results: 21 patients had benign thyroid nodules and 79 patients had malignant nodules. The average size of benign tumors and malignant tumors were 3.1±1.1 ㎝ and 2.1±1.7 ㎝, respectively. The hTERT expression was higher in malignant tumors (82.3%) than in benign tumors (9.5%) and that difference was statistically significant. In metastatic lymph nodes status of thyroid cancers, 45 of 65 patients (69.2%) had lymphatic metastases in hTERT positive group, which is much higher than hTERT negative group (P=0.001).
Conclusion: In our study, hTERT expression may be used as a prognostic biologic marker in thyroid cancer and also in the diagnosis of malignancy.
Methods: We examined the clinical data such as age, sex, and recurrence status of 100 patients that underwent thyroidectomy. Also, we reviewed the pathological data of the tissues (tumor size, lymph nodes, capsular invasion, perivascular invasion, perilymphatic invasion etc.). We checked hTERT expression by Allred scoring system using immunohistochemical staining.
Results: 21 patients had benign thyroid nodules and 79 patients had malignant nodules. The average size of benign tumors and malignant tumors were 3.1±1.1 ㎝ and 2.1±1.7 ㎝, respectively. The hTERT expression was higher in malignant tumors (82.3%) than in benign tumors (9.5%) and that difference was statistically significant. In metastatic lymph nodes status of thyroid cancers, 45 of 65 patients (69.2%) had lymphatic metastases in hTERT positive group, which is much higher than hTERT negative group (P=0.001).
Conclusion: In our study, hTERT expression may be used as a prognostic biologic marker in thyroid cancer and also in the diagnosis of malignancy.
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서론
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결과
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REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Mazzaferri EL / 1993 / Management of a solitary thyroid nodule / N Engl J Med 328 : 553 ~ 559
2. [학술지(정기간행물)] - Ridgway EC / 1992 / Clinical review 30: Clinician's evaluation of a solitary thyroid nodule / J Clin Endocrinol Metab 74 : 231 ~ 235
3. [학술지(정기간행물)] - Yoder BJ / 2006 / Validation of a five-tier cytodiagnostic system for thyroid fine needle aspiration biopsies using cytohistologic correlation / Thyroid 16 : 781 ~ 786
4. [학술지(정기간행물)] - Morgan JL / 2003 / Fine-needle aspiration cytology of thyroid nodules: how useful is it? / ANZ J Surg 73 : 480 ~ 483
5. [학술지(정기간행물)] - Kim NW / 1994 / Specific association of human telomerase activity with immortal cells and cancer / Science 266 : 2011 ~ 2015
2. [학술지(정기간행물)] - Ridgway EC / 1992 / Clinical review 30: Clinician's evaluation of a solitary thyroid nodule / J Clin Endocrinol Metab 74 : 231 ~ 235
3. [학술지(정기간행물)] - Yoder BJ / 2006 / Validation of a five-tier cytodiagnostic system for thyroid fine needle aspiration biopsies using cytohistologic correlation / Thyroid 16 : 781 ~ 786
4. [학술지(정기간행물)] - Morgan JL / 2003 / Fine-needle aspiration cytology of thyroid nodules: how useful is it? / ANZ J Surg 73 : 480 ~ 483
5. [학술지(정기간행물)] - Kim NW / 1994 / Specific association of human telomerase activity with immortal cells and cancer / Science 266 : 2011 ~ 2015
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UCI(KEPA) : I410-ECN-0101-2013-514-002678180