지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 218 - 223 (6page)
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초록· 키워드
오류제보하기
Background : Although the pericentric inversion of chromosome 9, inv(9)(p11q13), is generally considered a normal variation, it is also associated with solid tumors and several hematologic malignancies such as biphenotypic acute leukemia, ALL, AML, and myeloproliferative neoplasms.
However, to the best of our knowledge, there have been no reports that suggest an association between CML and constitutional pericentric inversion of chromosome 9. The purpose of this retrospective study was to investigate the frequency and clinical features of CML patients with concomitant inv(9) and t(9;22)(q34;q11.2) variation at our institution.
Methods : We reviewed the bone marrow chromosome database entries between October 2006 and December 2008 to identify patients with concomitant inv(9) and t(9;22) variations. Laboratory and clinical data of the patients were obtained from the electronic medical record system.
Results : Among the 51 CML patients, 4 (7.8%) had concomitant inv(9) and t(9;22) variations.
Conclusions : Although the association between inv(9) variation and CML is still controversial, we believe that hematologists should consider the role of constitutional inv(9) variation in CML patients to avoid overlooking the impaired engraftment potential of hematopoietic stem cells harboring inv(9). Therefore, we suggest that more effort should be invested to develop cytogenetic tests for detecting constitutional inv(9) variation in CML patients. (Korean J Lab Med 2010;30:218-23)
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Alimena G / 1985 / Cytogenetic pattern in leukemic cells of patients with constitutional chromosome anomalies / Cancer Genet Cytogenet 16 : 207 ~ 218
Benitez J / 1987 / Frequency of constitutional chromosome alterations in patients with hematologic neoplasias / Cancer Genet Cytogenet 24 : 345 ~ 354
Bernstein R / 1984 / The incidence, type, and subsequent evolution of 14 variant Ph1 translocations in 180 South African patients with Ph1-positive chronic myeloid leukemia
Betz JL / 2005 / Tirtorahardjo B, Moore MW, Cotter PD. Acquired inv(9): what is its significance? / Cancer Genet Cytogenet 160 : 76 ~ 78
Cerretini R / 2002 / Evaluation of constitutional chromosome aberrations in hematologic disorders / Cancer Genet Cytogenet 134 : 133 ~ 137
Benitez J / 1987 / Frequency of constitutional chromosome alterations in patients with hematologic neoplasias / Cancer Genet Cytogenet 24 : 345 ~ 354
Bernstein R / 1984 / The incidence, type, and subsequent evolution of 14 variant Ph1 translocations in 180 South African patients with Ph1-positive chronic myeloid leukemia
Betz JL / 2005 / Tirtorahardjo B, Moore MW, Cotter PD. Acquired inv(9): what is its significance? / Cancer Genet Cytogenet 160 : 76 ~ 78
Cerretini R / 2002 / Evaluation of constitutional chromosome aberrations in hematologic disorders / Cancer Genet Cytogenet 134 : 133 ~ 137
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