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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 260 - 263 (4page)
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초록· 키워드
오류제보하기
Factor VIII inhibitors are produced during or after coagulation factor VIII (FVIII) therapy in hemophilia A patients. These inhibitors are usually detected by a modified Bethesda assay or an enzymelinked immunosorbent assay (ELISA). In this study, we used the Bethesda assay to determine the incidence of FVIII inhibitors in 75 fresh plasma samples obtained from 50 hemophilia A patients, and then used ELISA and the Bethesda assay to determine the titres of these inhibitors after the samples had been frozen and thawed. The samples from the screening Bethesda assay were centrifuged and stored at -70℃in accordance with the assay guidelines. Subsequently, these samples were thawed and analyzed using ELISA and the Bethesda assay. The incidence of inhibitors in hemophilia A patients was 20.0%. Among the 35 inhibitor-positive samples identified in the screening Bethesda assay, 16 were positive in ELISA while only 4 were positive in the repeated Bethesda assay. In this study, the ELISA technique showed a higher sensitivity than the Bethesda assay in the detection of FVIII inhibitors in samples that were subjected to freezing and thawing procedures; this was because the Bethesda assay could not identify the FVIII inhibitors that were degraded after freezing and thawing. (Korean J Lab Med 2010;30:260-3)
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Barthels M / 1999 / Factor VIII inhibitor-tests could be less sensitive than supposed / Vox Sang 77 (S1) : s87 ~ s89
Bray GL / 1994 / Manco-Johnson M, et al. A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients
Clinical and Laboratory Standards Institute / 2008 / Collection, transport, and processing of blood specimens for testing plasma-based coagulation assays and molecular memostasis assay
Ehrenforth S / 1992 / Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs / Lancet 339 : 598 ~
Gringeri A / 2003 / Cost of care and quality of life for patients with hemophilia complicated by inhibitors:the COCIS Study Group / Blood 102 : 2358 ~ 2363
Bray GL / 1994 / Manco-Johnson M, et al. A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients
Clinical and Laboratory Standards Institute / 2008 / Collection, transport, and processing of blood specimens for testing plasma-based coagulation assays and molecular memostasis assay
Ehrenforth S / 1992 / Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs / Lancet 339 : 598 ~
Gringeri A / 2003 / Cost of care and quality of life for patients with hemophilia complicated by inhibitors:the COCIS Study Group / Blood 102 : 2358 ~ 2363
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