Bethesda Classification에 의거한 갑상선 세침흡인 검사 결과 분석 및 Atypical Cells of Undetermined Significance의 임상적 의의에 대한 고찰

강성준; 장정택; 김광민; 박준범; 배금석; 조미연

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자료유형: 학술저널

저자정보: 강성준 장정택 김광민 박준범 배금석 조미연

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제10권 제4호

발행연도: 2010.1

수록면: 240 - 244 (5page)

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Purpose: The frequency of diagnosis of each nodule category under the Bethesda classification was studied, and the differences in the results between cytopathologic and histopathologic analyses of same patients were assessed. Special attention was paid to the atypical cells of undetermined significance (ACUS), which is an intermediate category. The histopathology of ACUS specimens was confirmed to examine the clinical implication. Methods: Patients (n=417) who underwent thyroid ultrasonography and fine needle aspiration of the thyroid since the application of Bethesda classification (November 2009 to August 2010) in this institution was enrolled in the study. Results: According to the Bethesda criteria, of the 640 nodules there were 56 cases (8.8%) of ACUS, 14 cases (2.2%) of follicular neoplasm, 13 cases (2.0%) were suspicious for malignancy, and 37 cases (5.8%) were positive of malignancy. A total of 102 surgically-excised specimens were obtained, of which 40 specimens were previously categorized cytopathologically as ACUS. Of these 40 specimens, 16 cases (40%) were found to be malignant. Conclusion: A precise understanding of each diagnostic category seems to be necessary, which may help with treatment of patients with thyroid mass. This is especially true for ACUS, which was previously understood as an intermediate specimen, but which is actually a heterogeneous mix of benign specimen, benign specimen with various atypia, and malignancy. In case of ACUS, an extensive and accurate diagnostic approach utilizing various examination methods may be beneficial for the patient treatment. (Korean J Endocrine Surg 2010;10:240-244)

#세침 흡인 세포검사 #베데스다 분류법 #의미미결정비정형편평세포 #Fine needle aspiration cytology #Bethesda classification #Atypical cells of undetermined significance

참고문헌 (24)

참고문헌 신청

Alexander EK / 2002 / Assessment of nondiagnostic ultrasound- guided fine needle aspirations of thyroid nodules / J Clin Endocrinol Metab 87 : 4924 ~ 4927

Amrikachi M / 2001 / Accuracy of fine-needle aspiration of thyroid / Arch Pathol Lab Med 125 : 484 ~ 488

Baek JB / 2009 / The correlation between the fine needle aspiration cytology and histology of patients who have undergone thyroidectomy / Endocrine 9 : 223 ~ 227

Baloch ZW / 2008 / The National Cancer Institute Thyroid fine needle aspiration state of the science conference: a summation / Cytojournal 5 : 6 ~

Cibas ES / 2009 / The bethesda system for reporting thyroid cytopathology / Am J Clin Pathol 132 : 658 ~ 665

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