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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 201 - 206 (6page)
이용수
초록· 키워드
오류제보하기
Background : Atrophic gastritis is a well known risk factor for gastric adenocarcinoma. Its confirmatory
diagnosis requires histology via endoscopy, which is an invasive method; therefore, periodic
follow up evaluation as a screening method is difficult to perform. We evaluated the clinical utility
of serum pepsinogens (PG) as a biomarker for screening of atrophic gastritis.
Methods : The study population consisted of 130 selected dyspeptic patients (M:F=52:78; age,
16-105 yrs; mean age, 50.8 yrs) who had undergone a diagnostic endoscopy. The serum pepsinogen
test was performed by a latex turbidimetric immunoassay method (HBI, Korea) using Toshiba-
200FR automatic analyzer. The PGI, II level and PGI:PGII ratio of non-atrophic gastritis group were
compared with those of atrophic gastritis group, and a correlation with Helicobacter pylori infection
was examined. Cut-off points for screening of atrophic gastritis were determined.
Results : The mean serum concentration of PGI showed a decline from normal (60.7 ng/mL), nonatrophic
gastritis (54.2 ng/mL), and atrophic gastritis (51.8 ng/mL) to gastric adenocarcinoma (32.6
ng/mL). The mean ratio of PGI:PGII was lower in atrophic gastritis (3.2) compared to non-atrophic
gastritis (4.7) (P=0.021). In patients with H. pylori infection, the mean serum PGII level was higher
and the PGI:PGII ratio was lower than those in patients without H. pylori infection, and the differences
were statistically significant. For screening of atrophic gastritis, the best cut-off point of PGI:PGII ratio
was 4, with a sensitivity of 82.6% and specificity of 91.7%.
Conclusions : The serum pepsinogen test is a useful biomarker for screening of atrophic gastritis,
a well-known precancerous lesion of gastric adenocarcinoma. Measuring both pepsinogen I
and II concentrations simultaneously to obtain pepsinogen I/II ratio provides a clinically useful information
for the detection of atrophic gastritis. (Korean J Lab Med 2008;28:201-6)
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Aoki K / 1997 / Evaluation of cutoff levels for screening of gastric cancer using serum pepsinogens and distributions of levels of serum pepsinogen I, II and of PG I/PG II r
Broutet N / 2003 / Eurohepygast Study Group. Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics / Br J Cancer 88 : 1239
Di Gregorio C / 1993 / Gastric dysplasia. A follow-up study / Am J Gastroenterol 88 : 1714 ~ 1719
Fukuda H / 1995 / Helicobacter pylori infection, serum pepsinogen level and gastric cancer: a case-control study in Japan / Jpn J Caner Res 86 : 64 ~ 71
Hai-Rim Shin / 2004 / 2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals / Cancer Research and Treatment 36 (2) : 103 ~ 114
Broutet N / 2003 / Eurohepygast Study Group. Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics / Br J Cancer 88 : 1239
Di Gregorio C / 1993 / Gastric dysplasia. A follow-up study / Am J Gastroenterol 88 : 1714 ~ 1719
Fukuda H / 1995 / Helicobacter pylori infection, serum pepsinogen level and gastric cancer: a case-control study in Japan / Jpn J Caner Res 86 : 64 ~ 71
Hai-Rim Shin / 2004 / 2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals / Cancer Research and Treatment 36 (2) : 103 ~ 114
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