한 농촌지역 주민에서 성, 연령 및 Helicobacter pylori 감염 여부에 따른 위축성 위염과 장상피화생 유병률

김현자; 최보율; 변태준; 은창수; 송규상; 김용성; 한동수

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자료유형: 학술저널

저자정보: 김현자 최보율 변태준 은창수 송규상 김용성 한동수

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제41권 제6호

발행연도: 2008.1

수록면: 373 - 379 (7page)

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Objectives : The objective of this study was to evaluate the prevalence of atrophic gastritis and intestinal metaplasia according to gender, age and Helicobacter pylori infection in a rural population in Korea. Methods: Between April 2003 and January 2007, 713 subjects (298 men and 415 women, age range: 18-85) among the 2,161 adults who participated in a populationbased survey received gastrointestinal endoscopy. All the subjects provided informed consent. Multiple biopsy specimens were evaluated for the presence of atrophic gastritis and intestinal metaplasia. The presence of Helicobacter pylori was determined using CLO and histology testing. Results : The age-adjusted prevalence of atrophic gastritis was 42.7% for men and 38.1% for women and the prevalence of intestinal metaplasia was 42.5% for men and 32.7% for women. The prevalence of atrophic gastritis and intestinal metaplasia increased significantly with age for both men and women (p for trend<0.001). The ageadjusted prevalence of Helicobacter pylori was similar for men (59.0%) and women (56.7%). The subjects with Helicobacter pylori infection showed a significantly higher prevalence of intestinal metaplasia (44.3%) compared with that (26.8%) of the noninfected subjects (p<0.001). However, the prevalence of atrophic gastritis was not statistically different between the Helicobacter pyloriinfected subjects and the noninfected individuals. Conclusions : Our findings suggest that the prevalence of atrophic gastritis and intestinal metaplasia is higher for a Korean rural population than that for a Western population; this may be related to the high incidence of gastric cancer in Koreans. Especially, the prevalence of intestinal metaplasia was high for the subjects with Helicobacter pylori infection. The multistep process of gastric carcinogenesis and the various factors contributing to each step of this process need to be determined by conducting future follow-up studies.

Objectives : The objective of this study was to evaluate the prevalence of atrophic gastritis and intestinal metaplasia according to gender, age and Helicobacter pylori infection in a rural population in Korea. Methods: Between April 2003 and January 2007, 713 subjects (298 men and 415 women, age range: 18-85) among the 2,161 adults who participated in a populationbased survey received gastrointestinal endoscopy. All the subjects provided informed consent. Multiple biopsy specimens were evaluated for the presence of atrophic gastritis and intestinal metaplasia. The presence of Helicobacter pylori was determined using CLO and histology testing. Results : The age-adjusted prevalence of atrophic gastritis was 42.7% for men and 38.1% for women and the prevalence of intestinal metaplasia was 42.5% for men and 32.7% for women. The prevalence of atrophic gastritis and intestinal metaplasia increased significantly with age for both men and women (p for trend<0.001). The ageadjusted prevalence of Helicobacter pylori was similar for men (59.0%) and women (56.7%). The subjects with Helicobacter pylori infection showed a significantly higher prevalence of intestinal metaplasia (44.3%) compared with that (26.8%) of the noninfected subjects (p<0.001). However, the prevalence of atrophic gastritis was not statistically different between the Helicobacter pyloriinfected subjects and the noninfected individuals. Conclusions : Our findings suggest that the prevalence of atrophic gastritis and intestinal metaplasia is higher for a Korean rural population than that for a Western population; this may be related to the high incidence of gastric cancer in Koreans. Especially, the prevalence of intestinal metaplasia was high for the subjects with Helicobacter pylori infection. The multistep process of gastric carcinogenesis and the various factors contributing to each step of this process need to be determined by conducting future follow-up studies.

#Atrophic gastritis #Helicobacter pylori #Korea #Metaplasia #Prevalence

참고문헌 (24)

참고문헌 신청

Asaka M / 2001 / Atrophic gastritis and intestinal metaplasia in Japan: Results of a large multicenter study / Helicobacter 6 (4) : 294 ~ 299

Borch K / 2000 / Prevalence of gastroduodenitis and Helicobacter pylori infection in a general population sample: Relations to symptomatology and life-style / Dig Dis Sci 45

Choi KH / 1996 / Prevalence of Helicobacter pylori infection

Classification and grading of gastritis. The updated Sydney system / 1996 / Classification and grading of gastritis, The updated Sydney system / Am J Surg Pathol 20 (10) : 11

Coma del Corral MJ / 1990 / Risk of cancer in patients with gastric dysplasia. Follow-up study of 67 patients / Cancer 65 (9) : 2078 ~ 2085

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