Associations among Gastric Juice pH, Atrophic Gastritis, Intestinal Metaplasia and Helicobacter pylori Infection

Jihee Sung; Nayoung Kim; Jongchan Lee; Young-Jae Hwang; Hyoung Woo Kim; Jung Wha Chung; Jin-Wook Kim; Dong Ho Lee

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자료유형: 학술저널

저자정보: Jihee Sung Nayoung Kim Jongchan Lee Young-Jae Hwang Hyoung Woo Kim Jung Wha Chung Jin-Wook Kim Dong Ho Lee

저널정보: 거트앤리버 발행위원회 Gut and Liver Gut and Liver 제12권 제2호

발행연도: 2018.1

수록면: 158 - 164 (7page)

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Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio, and interleukin (IL)-1β levels were measured. Results: The mean pH of gastric juice was higher in the H. pylori-positive group (n=17) than that in the H. pylori-negative group (n=29) (4.54 vs 2.46, p=0.002). When patients were divided into pH <3 (n=28) and pH ≥3 (n=18) groups, H. pylori was lower in the pH <3 group (21.4%) than in the pH ≥3 group (61.1%) (p=0.007). The pH ≥3 group demonstrated AG and IM more frequently than the pH <3 group in the body (p=0.047 and p=0.051, respectively) but not in the antrum. There were no differences in pepsinogen I or II, I/II ratio, and IL-1β levels between the two groups. Conclusions: There is a relationship between chronic H. pylori infection and gastric juice pH ≥3, which may originate from AG and IM in the body.

참고문헌 (28)

참고문헌 신청

Waldum HL / 2014 / The regulation of gastric acid secretion: clinical perspectives / Acta Physiol (Oxf) 210:239~256

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Wilder-Smith CH / 1992 / Bactericidal factors in gastric-juice / Eur J Gastroenerol Hepatol 4:885~891

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이 논문의 저자 정보

Jihee Sung

소속기관 Department of Internal Medicine Seoul National University Bundang Hospital

주요연구분야 의약학 > 기초의학 > 예방의학·직업환경의학 의약학 > 임상의학 > 내과학

논문수 4 이용수 1

Nayoung Kim

소속기관 Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea

주요연구분야 의약학 > 임상의학 > 가정의학 의약학 > 임상의학 > 내과학

논문수 26 이용수 10

Jongchan Lee