지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Direct injection of a fibrinolytic agent to the intraarterial thrombosis may increase the effectiveness of thrombolysis by enhancing the permeation of thrombolytic agents into the blood clot. Permeation of fibrinolytic agents into a clot is influenced by the surface pressure, which is determined by the injection velocity of fibrinolytic agents. In order to calculate the pressure distribution on the clot surface for different jet velocities (1, 3, 5 m/sec) and nozzle arrangements (1, 9, 17 nozzles), computational fluid dynamic methods were used. Thrombolysis of a clot was mathematically modeled based on the pressure and lysis front velocity relationship. Direct injection of a thrombolytic agent increased the speed of thrombolysis significantly and the effectiveness was increased as the ejecting velocity increased. The nine nozzles model showed about 20% increase of the lysed volume, and the one and seventeen nozzles models did not show significant differences. The wall shear stress decreased as the number of nozzles increased, and the wall shear stress in most vessel wall was lower than 25 Pa. The results implied that thrombolysis could be accelerated by direct injection of a drug with the moderate velocity without damaging the blood vessel wall.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
/ 1968. / Acute vascular endothelrial changes associated with increased blood velocity gradients 22 : 165 ~ 182
/ 1992. / Lysis patterns of retracted blood clots with diffusion or bulk flow transport of urokinase into the clot a magnetic resonance imaging study in vitro 68 : 667 ~ 671
/ 1994. / Flow through clots determines the rate and pattern of fibrinolysis 71 : 230 ~ 235
/ 1994. / Thrombolytic therapy for arterial occlusion 60 : 371 ~ 375
/ 1994. / Transport phenomena and clot dissolving therapy:An experimental investigation of diffusion controlled and permeation enhanced fibrinolysis 72 : 105 ~ 112
/ 1992. / Lysis patterns of retracted blood clots with diffusion or bulk flow transport of urokinase into the clot a magnetic resonance imaging study in vitro 68 : 667 ~ 671
/ 1994. / Flow through clots determines the rate and pattern of fibrinolysis 71 : 230 ~ 235
/ 1994. / Thrombolytic therapy for arterial occlusion 60 : 371 ~ 375
/ 1994. / Transport phenomena and clot dissolving therapy:An experimental investigation of diffusion controlled and permeation enhanced fibrinolysis 72 : 105 ~ 112
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