Month and Season of Birth as a Risk Factor for Alzheimer's Disease: A Nationwide Nested Case-control Study

Anna-Maija Tolppanen; Riitta Ahonen; Marjaana Koponen; Piia Lavikainen; Maija Purhonen; Heidi Taipale; Antti Tanskanen; Jari Tiihonen; Miia Tiihonen; Sirpa Hartikainen

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자료유형: 학술저널

저자정보: Anna-Maija Tolppanen Riitta Ahonen Marjaana Koponen Piia Lavikainen Maija Purhonen Heidi Taipale Antti Tanskanen Jari Tiihonen Miia Tiihonen Sirpa Hartikainen

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제49권 제2호

발행연도: 2016.1

수록면: 134 - 138 (5page)

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Objectives: Season of birth, an exogenous indicator of early life environment, has been related to higher risk of adverse psychiatric outcomes but the findings for Alzheimer’s disease (AD) have been inconsistent. We investigated whether the month or season of birth are associated with AD. Methods: A nationwide nested case-control study including all community-dwellers with clinically verified AD diagnosed in 2005 to 2012 (n=70 719) and up to four age- sex- and region of residence-matched controls (n=282 862) residing in Finland. Associations between month and season of birth and AD were studied with conditional logistic regression. Results: Month of birth was not associated with AD (p=0.09). No strong associations were observed with season (p=0.13), although in comparison to winter births (December-February) summer births (June-August) were associated with higher odds of AD (odds ratio, 1.03; 95% confidence interval, 1.00 to 1.05). However, the absolute difference in prevalence in winter births was only 0.5% (prevalence of those born in winter were 31.7% and 32.2% for cases and controls, respectively). Conclusions: Although our findings do not support the hypothesis that season of birth is related to AD/dementia risk, they do not invalidate the developmental origins of health and disease hypothesis in late-life cognition. It is possible that season does not adequately capture the early life circumstances, or that other (postnatal) risk factors such as lifestyle or socioeconomic factors overrule the impact of prenatal and perinatal factors.

#Risk factors #Seasons #Case-control studies #Alzheimer disease

참고문헌 (20)

참고문헌 신청

Whalley LJ / 2006 / A life-course approach to the aetiology of late-onset dementias / Lancet Neurol 5(1):87~96

Barker DJ / 2007 / The origins of the developmental origins theory / J Intern Med 261(5):412~417

Doblhammer G / 2015 / Month of birth and dementia late in life / Kolner Z Soz Sozpsychol 67(Suppl 1):217~240

Castrogiovanni P / 1998 / Season of birth in psychiatry. A review / Neuropsychobiology 37(4):175~181

Gardener H / 2010 / Prenatal and early life factors and risk of Parkinson’s disease / Mov Disord 25(11):1560~1567

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