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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 263 - 270 (8page)
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Purpose: To quantify the effects of irradiation on the expression levels of a differentially expressed gene, RTP801, in HeLa cells. Materials and Methods: Total RNA was isolated from irradiated and non-irradiated HeLa cells. A subtraction library was constructed, from which 88 random clones were screened. The expression patterns of one clone, detected by reverse Northern blotting, were quantified by real time RT-PCR, using CYBR green I dye. Results: RTP801, a hypoxia-inducible factor-I-responsive gene, was identified as a differentially expressed gene in HeLa cells exposed to X-ray. Real time RT-PCR showed that the mRNA levels of RTP801 were greatly diminished by radiation. Conclusions: These results suggest that down-regulation of hypoxia-inducible factor-I-responsive genes, such as RTP801, in irradiated HeLa cells may result in reductions in the radiotherapy resistance of tumor cells.(Cancer Res Treat. 2004;36:263-270)
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참고문헌 (25)
참고문헌 신청
/ / The differentially expressed genes by radiotherapy in thepatients with uterine cervical cancer 21
/ 1992 / A nuclear factor induced byhypoxia via de novo protein synthesis binds to human erythropoietingene enhancer at a site required for transcriptionalactivation 12 : 54
/ 1993 / Beneficial liaisons:radiobiology meets cellularand molecular biology 28 : 1 ~ 15
/ 1994 / Oxygen regulated control elements in phosphoglycerate kinase 1 and lactatedehydrogenase A genes:similarities with the erythropoietin 3'enhancer 91 : 6496 ~ 6500
/ 1994 / Transcriptionalregulation of genes encoding glycolytic enzymes byhypoxia-inducible factor 269 : 23757 ~ 23763
/ 1992 / A nuclear factor induced byhypoxia via de novo protein synthesis binds to human erythropoietingene enhancer at a site required for transcriptionalactivation 12 : 54
/ 1993 / Beneficial liaisons:radiobiology meets cellularand molecular biology 28 : 1 ~ 15
/ 1994 / Oxygen regulated control elements in phosphoglycerate kinase 1 and lactatedehydrogenase A genes:similarities with the erythropoietin 3'enhancer 91 : 6496 ~ 6500
/ 1994 / Transcriptionalregulation of genes encoding glycolytic enzymes byhypoxia-inducible factor 269 : 23757 ~ 23763
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