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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 301 - 310 (10page)
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초록· 키워드
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Purpose: This investigation is intended to obtain differentially expressed genes related to human malignant glioma using Subtractive hybridization. Materials and Methods: Subtractive hybridization is potentially faster methods for identifying differentially expressed genes associated with a particular disease state. We identified 7 over-expressed genes which were not homologous to any of the known genes in the GenbankTM database. Results: Using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), the mRNA expression levels of these 7 genes were higher in human glioblastomas tissue than in non-tumor brain tissue. In order to learn more about the expression profile of these genes, RT-PCR was performed using various commercially available human carcinoma cell lines. Some of these new genes were over-expressed in human glioma cell line, but not the expressed in other human cancer cell line. Conclusion: Theses cloned new genes may play a role in brain tumorigenesis. Further studies including verification of oncogene, cancer protein, and glioblastoma induction in animal model are needed.
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참고문헌 (22)
참고문헌 신청
Chook YM / 2001 / Karyopherins and nuclear import / Curr Opin Struct Biol 1 : 703 ~ 715
Christensen HC / 2003 / Incidences of gliomas and meningiomas in Denmark, 1943 to 1997 / Neurosurgery 52 : 1327 ~ 1333
Dai C / 2003 / Astrocyte differentiation states and gliomas formation / Cancer J 9 : 72 ~ 81
Diatchenko L / 1996 / Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries / Proc Natl Acad S
Dong Y / 2003 / Ip C. Delineation of the molecular basis for selenium- induced growth arrest in human prostate cancer cells by oligonucleotide array / Cancer Res 63 : 52 ~ 5
Christensen HC / 2003 / Incidences of gliomas and meningiomas in Denmark, 1943 to 1997 / Neurosurgery 52 : 1327 ~ 1333
Dai C / 2003 / Astrocyte differentiation states and gliomas formation / Cancer J 9 : 72 ~ 81
Diatchenko L / 1996 / Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries / Proc Natl Acad S
Dong Y / 2003 / Ip C. Delineation of the molecular basis for selenium- induced growth arrest in human prostate cancer cells by oligonucleotide array / Cancer Res 63 : 52 ~ 5
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