지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Genetic factors clearly play a role in carcinogenesis, but
migrant studies provide unequivocal evidence that
environmental factors are critical in defining cancer risk.
Therefore, one may expect that the lower availability of
substrate for biochemical reactions leads to more genetic
changes in enzyme function; for example, most studies
have indicated the variant MTHFR genotype 677TT is
related to biomarkers, such as homocysteine concentrations
or global DNA methylation particularly in a low
folate diet.
The modification of a phenotype related to a genotype,
particularly by dietary habits, could support the notion that
some of inconsistencies in findings from molecular
epidemiologic studies could be due to differences in the
populations studied and unaccounted underlying
characteristics mediating the relationship between genetic
polymorphisms and the actual phenotypes. Given the
evidence that diet can modify cancer risk, gene-diet
interactions in cancer etiology would be anticipated.
However, much of the evidence in this area comes from
observational epidemiology, which limits the causal
inference. Thus, the investigation of these interactions is
essential to gain a full understanding of the impact of
genetic variation on health outcomes.
This report reviews current approaches to gene-diet
interactions in epidemiological studies. Characteristics of
gene and dietary factors are divided into four categories:
one carbon metabolism-related gene polymorphisms and
dietary factors including folate, vitamin B group and
methionines; oxidative stress-related gene polymorphisms
and antioxidant nutrients including vegetable and fruit
intake; carcinogen-metabolizing gene polymorphisms and
meat intake including heterocyclic amins and polycyclic
aromatic hydrocarbon; and other gene-diet interactive
effect on cancer.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
[학술지
Ames BN / 2001 / DNA damage from micronutrient deficiencies is likely to be a major cause of cancer / Mutat Res 475 (1) : 7 ~ 20
Beetstra S / 2005 / Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei / Mutat Res 578 (1) : 3
Chen J / 2005 / One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer / Cancer Res 65 (4) : 1606 ~ 1614
Duthie SJ / 1999 / Folic acid deficiency and cancer:Mechanisms of DNA instability / Br Med Bull 55 (3) : 578 ~ 592
Ames BN / 2001 / DNA damage from micronutrient deficiencies is likely to be a major cause of cancer / Mutat Res 475 (1) : 7 ~ 20
Beetstra S / 2005 / Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei / Mutat Res 578 (1) : 3
Chen J / 2005 / One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer / Cancer Res 65 (4) : 1606 ~ 1614
Duthie SJ / 1999 / Folic acid deficiency and cancer:Mechanisms of DNA instability / Br Med Bull 55 (3) : 578 ~ 592
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대한수의사회지
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Association between Genetic Variation in the Human Factor Ⅶ Gene and Essential Hypertension in Korean Population
한국환경성돌연변이·발암원학회지
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No Association between Polymorphisms of Vitamin D and Oxytocin Receptor Genes and Autistic Spectrum Disorder in a Sample of Turkish Children
Clinical Psychopharmacology and Neuroscience
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The 2518 A/G Polymorphism in the MCP-1 Gene and Cancer Risk: A Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
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Mutational Analysis of the MTHFR Gene in Breast Cancer Patients of Pakistani Population
Asian Pacific journal of cancer prevention : APJCP
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Insertion/deletion (I/D) in the Angiotensin-converting Enzyme Gene and Breast Cancer Risk: Lack of Association in a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
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MTHFR Gene Polymorphisms are Not Involved in Pancreatic Cancer Risk: A Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
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