지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Evidences supporting gene-environment interaction are accumulating in terms of environmental exposure including lifestyle factors and related genetic variants. One form of defense mechanism against cancer development involves a series of genes whose role is to metabolize (activation/detoxification) and excrete potentially toxic compounds and to repair subtle mistakes in DNA. The purpose of this article is to provide a brief review of the notion of gene-environment interaction, environmental/occupational carcinogens and related cancers, and previous studies of gene-environment interaction on cancers caused by exposure to carcinogenesis. With a number of studies on the interaction between lifestyle factors (e.g., smoking and diet) and genetic polymorphisms in genes involved in xenobiotic metabolism and DNA repair excluded, only several studies have been conducted on the interactive effects between polymorphisms of CYPs,GSTs, ERCCs, XRCCs and environmental/occupational carcinogens such as vinyl chloride, benzo[a]pyrene, and chloroform on carcinogenesis or genotoxicity. Future studies may need to be conducted with sufficient number of subjects and based on occupational cohorts to provide useful information in terms of advanced risk assessment and regulation of exposure level.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ 2005 / National Toxicology Program, Carcinogens listed in the eleventh report
Berwick,M / 2000 / Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review / Journal of the National Cancer Institute 92 (11) : 874 ~ 897
Capella, G / 2008 / DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study / International Journal of Epidemio
Carporaso, N / 1999 / Selection of candidate genes for population studies / in Metabolic polymorhisms and susceptibility to cancer
Cuzick, J / 1999 / Interaction, subgroup analysis and sample size. Metabolic polymorphisms and susceptibility to cancer / IARC Scientific Publishers
Berwick,M / 2000 / Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review / Journal of the National Cancer Institute 92 (11) : 874 ~ 897
Capella, G / 2008 / DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study / International Journal of Epidemio
Carporaso, N / 1999 / Selection of candidate genes for population studies / in Metabolic polymorhisms and susceptibility to cancer
Cuzick, J / 1999 / Interaction, subgroup analysis and sample size. Metabolic polymorphisms and susceptibility to cancer / IARC Scientific Publishers
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