Vascular Endothelial Growth Factor (VEGF) Gene Polymorphisms and Breast Cancer Risk in a Chinese Population

Luo, Ting; Chen, Long; He, Ping; Hu, Qian-Cheng; Zhong, Xiao-Rong; Sun, Yu; Yang, Yuan-Fu; Tian, Ting-Lun; Zheng, Hong

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자료유형: 학술저널

저자정보: Luo, Ting (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West) Chen, Long (Department of Laboratory Medicine, West China Hospital, Sichuan University) He, Ping (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer, West) Hu, Qian-Cheng (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cancer,) Zhong, Xiao-Rong (Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, Laboratory of Molecular Diagnosis of Cance) Sun, Yu (Department of Head & Neck a) Yang, Yuan-Fu Tian, Ting-Lun Zheng, Hong

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제4호

발행연도: 2013.1

수록면: 2,433 - 2,437 (5page)

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Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis and thereby involved in the development and progression of solid tumours. Associations between three VEGF gene polymorphisms (-634 G/C, +936 C/T, and +1612 G/A) and breast cancer risk have been extensively studied, but the currently available results are inconclusive. Our aim was to investigate associations between three VEGF gene polymorphisms and breast cancer risk in Chinese Han patients. We performed a hospital-based case-control study including 680 female incident breast cancer patients and 680 female age-matched healthy control subjects. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect the three VEGF gene polymorphisms. We observed that women carriers of +936 TT genotypes [odds ratio (OR) =0.46, 95% confidence interval (CI) = 0.28, 0.76; P=0.002] or 936 T-allele (OR=0.81, 95% CI= 0.68, 0.98; P=0.03) had a protective effect concerning the disease. Our study suggested that the +1612G/A polymorphism was unlikely to be associated with breast cancer risk. The -634CC genotype was significantly associated with high tumor aggressiveness [large tumor size (OR=2.63, 95% CI=1.15, 6.02; P=0.02) and high histologic grade (OR=1.47, 95% CI= 1.06, 2.03; P=0.02)]. The genotypes were not related with other tumor characteristics such as regional or distant metastasis, stage at diagnosis, or estrogen or progesterone receptor status. Our study revealed that the VEGF -634 G/C and +936 C/T gene polymorphisms may be associated with breast cancer in Chinese Han patients.

#VEGF #single nucleotide polymorphism #breast cancer risk #Han Chinese

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Luo, Ting

소속기관 Department of Head & Neck and Mammary Oncology and Department of Medical Oncology, Cancer Center