지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 796 - 803 (8page)
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초록· 키워드
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Purpose KRASmutations have been used widely as prognostic or predictive marker in patients withadvanced colorectal cancer (CRC). However, it may be difficult to obtain a tumor tissue foranalyzing the status of KRAS mutation in large proportion of patients with advanceddisease.
Materials and MethodsWe obtained pairs of tumor and serum samples from 65 patients with advanced CRC,between March 2008 and July 2011. KRAS mutation status from the tumor samples wasanalyzed by genomic polymerase chain reaction and direct sequence, and KRASmutationstatus from the serum samples was determined by a genomic polymerase chain reaction–restriction fragment length polymorphism assay.
ResultsKRAS mutations were detected in the serum samples of 26 patients and in the tumorsamples of 31 patients. KRAS mutation status in the serum and tumor samples wasconsistent in 44 of the 65 pairs (67.7%). There was a significant correlation between themutations detected in the serum sample and the mutations detected in the matched tumorsample (correlation index, 0.35; p < 0.004). Twenty-two of the 57 patients (38.5%) receivedanti-epidermal growth factor receptor therapy as any line therapy. There was no significantdifference in the overall survival (OS) in accordance to the status of KRASmutations in boththe serum and tumor samples (p > 0.05). In a multivariate analysis, liver metastasis andno cytoreductive operation were independent prognostic factors for decreased OS.
ConclusionThe serum sample might alternatively be used when it is difficult to obtain
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참고문헌 (23)
참고문헌 신청
Amado RG / 2008 / Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer / J Clin Oncol 26 : 1626 ~ 1634
Andreyev HJ / 1998 / Kirsten ras mutations in patients with colorectal cancer : the multicenter"RASCAL"study / J Natl Cancer Inst 90 : 675 ~ 684
Andreyev HJ / 2001 / Kirsten ras mutations in patients with colorectal cancer : the 'RASCAL II' study / Br J Cancer 85 : 692 ~ 696
Anker P / 1997 / K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer / Gastroenterology 112 : 1114 ~ 1120
Baker SJ / 1990 / p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigene
Andreyev HJ / 1998 / Kirsten ras mutations in patients with colorectal cancer : the multicenter"RASCAL"study / J Natl Cancer Inst 90 : 675 ~ 684
Andreyev HJ / 2001 / Kirsten ras mutations in patients with colorectal cancer : the 'RASCAL II' study / Br J Cancer 85 : 692 ~ 696
Anker P / 1997 / K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer / Gastroenterology 112 : 1114 ~ 1120
Baker SJ / 1990 / p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigene
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