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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 80 - 86 (7page)
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초록· 키워드
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Purpose :
A novel chemically modified heparin derivative, heparin-deoxycholic acid nano-particles, has lower anticoagulant activity, and was recently reported to have significant anti-tumor effects on squamous head and neck cancer cells. Therefore, the aim of this study was to evaluate the anti-tumor effects of heparin-deoxycholic acid nano-particles in a human lung adenocarcinoma cell line.
Materials and Methods :
An orthotopic lung cancer model in 16 mice was developed using intra-thoracic injections of 0.5x106 PC14PE6 cells. Ten days after inoculation, the mice were divided into two groups.
PBS and Heparin-DOCA particles were injected once a day every 3 days in the tail vein, for a total of 5 injections. The body weight and survival of each mouse were monitored and the tumor size in the lung was measured by SPECT-CT before and after heparin-DOCA nanoparticle treatment.
Results :
IThe HD particles had no significant cytotoxicity when the PC9 cells were treated in vitro. There was no statistical difference in tumor size, body weight and survival between the HD treated and control groups in vivo. Furthermore, there was no difference in the amount of CD31 between tumor tissues in the two study groups.
Conclusion :
HD synthesized with unfractionated heparin had no apparent inhibitory effects on tumor growth in a PC14PE6 cell induced orthotopic lung cancer mouse model. The HD particles did not significantly inhibit tumor-induced angiogenesis at the tumor sites.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Borsig L / 2001 / Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins,and tumor metastasis / Proc Natl Acad Sci U S A 98
Hai-Rim Shin / 2007 / National Cancer Incidence for the Year 2002 in Korea / Cancer Research and Treatment 39 (4) : 139 ~ 149
Hong KJ / 2006 / A compact SPECT/CT system for small animal imaging / IEEE Trans Nucl Sci 53 : 2601 ~ 2604
Kakkar AK / 2004 / Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS) / J Clin On
Kelly K / 2001 / Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung ca
Hai-Rim Shin / 2007 / National Cancer Incidence for the Year 2002 in Korea / Cancer Research and Treatment 39 (4) : 139 ~ 149
Hong KJ / 2006 / A compact SPECT/CT system for small animal imaging / IEEE Trans Nucl Sci 53 : 2601 ~ 2604
Kakkar AK / 2004 / Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS) / J Clin On
Kelly K / 2001 / Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung ca
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