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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 234 - 239 (6page)
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초록· 키워드
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Purpose: This study was undertaken to investigate in detail the xenograft mouse orthotopic lung cancer model induced by PC14PE6 adenocarcinoma cells.
Materials and Methods: Three cell doses (0.5×106; 1×106; 2×106) of PC14PE6 cells were injected into the lungs of male BALB/c nude mice by the intrathoracic injection method. The lung and other organs, including brain, liver, spleen, kidney, muscle, adrenal gland, and lymph node on knee, were removed and stained with H/E to detect the presence of tumor cells.
Results: The reliable tumorigenicity time in the PC14PE6 adenocarcinoma cell-inoculated BALB/c nude mouse was 10 days after intrathoracic injection. The average life span of the three groups after inoculation was 14 days in the 2×106 cells inoculum group; 25 days in the 1×106 cells inoculum group; and 32 days in the 0.5×106 cells inoculum group. The PC14PE6 adenocarcinoma cells induced orthotopic lung cancer limited within the thorax.
Conclusions: This orthotopic lung cancer model is an efficient cancer model with easy inoculation methods, rapid and high tumorigenicity, and simple monitoring methods for metastasis. (Cancer Res Treat. 2006;38:234-239)
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참고문헌 (10)
참고문헌 신청
/ 1992 / Orthotopic growth and metastasis of human prostate carcinoma in nude mice after transplantation of histologically intact tissue 52 : 987 ~ 990
/ 1993 / Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue 53 : 1204 ~ 1208
/ 1997 / Metastasis results from preexisting variant cells within a malignant tumor 197 : 893 ~ 895
/ 1999 / Orthotopic metastatic mouse models for anticancer drug discovery and evaluation 17 : 343 ~ 359
/ 2002 / Activity of a new vascular targeting agent,ZD6126,in pulmonary metastases by human lung adenocarcinoma in nude mice 62 : 3711 ~ 3715
/ 1993 / Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue 53 : 1204 ~ 1208
/ 1997 / Metastasis results from preexisting variant cells within a malignant tumor 197 : 893 ~ 895
/ 1999 / Orthotopic metastatic mouse models for anticancer drug discovery and evaluation 17 : 343 ~ 359
/ 2002 / Activity of a new vascular targeting agent,ZD6126,in pulmonary metastases by human lung adenocarcinoma in nude mice 62 : 3711 ~ 3715
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