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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 118 - 120 (3page)
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Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy that consisted of infused 5-FU (1,000 mg/m2) for 5 days and cisplatin (60 mg/m2) on day 1 following total gastrectomy. Nineteen days after starting chemotherapy, the patient displayed a sudden onset of slurred speech, confusion, cognitive disturbances and paranoia. A magnetic resonance image (MRI) of the brain showed no structural abnormalities, and the other laboratory tests provided no explanations for her symptoms, other than a slightly elevated ammonia level. The patient was treated with a lactulose retention enema and thiamine infusion, the 5-FU was halted and her symptoms then recovered after 7 days.
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참고문헌 (12)
참고문헌 신청
Cheung WY / 2008 / The confused cancer patient: a case of 5- fluorouracil-induced encephalopathy / Curr Oncol 15 : 234 ~ 236
Etienne MC / 1994 / Population study of dihydropyrimidine dehydrogenase in cancer patients / J Clin Oncol 12 : 2248 ~ 2253
Grem JL / 2000 / 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development / Invest New Drugs 18 : 299 ~ 313
Heggie GD / 1987 / Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile / Cancer Res 47 : 2203 ~ 2206
Heier MS / 1989 / Effect of the fluoropyrimidines 5-fluorouracil and doxifluridine on cellular uptake of thiamin / Anticancer Res 9 : 1073 ~ 1077
Etienne MC / 1994 / Population study of dihydropyrimidine dehydrogenase in cancer patients / J Clin Oncol 12 : 2248 ~ 2253
Grem JL / 2000 / 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development / Invest New Drugs 18 : 299 ~ 313
Heggie GD / 1987 / Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile / Cancer Res 47 : 2203 ~ 2206
Heier MS / 1989 / Effect of the fluoropyrimidines 5-fluorouracil and doxifluridine on cellular uptake of thiamin / Anticancer Res 9 : 1073 ~ 1077
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