지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: This study aimed to investigate the preventive effect of red ginseng (RG) on 5-fluorouracil (5-FU)-induced side effects focusing on myelosuppression.
Methods: Rats (n = 50) were divided into five groups, nave, control (ip, 5-FU injection of 150 mg/kg), and RG pre-treatment (po, 25, 50 and 100 mg/kg for 5 days before 5-FU injection). On the 7th day after 5-FU injection, we evaluated the effects using peripheral hematological parameters, colony-forming assay, cytokine levels and histopathological finding.
Results: The peripheral white blood cell and the differential count were dramatically suppressed by 5-FU, while RG (50 and 100 mg/kg) treatment significantly improved total white blood cell, neutrophil, lymphocyte and platelet counts. Also, RG (100 mg/kg) pre-treatment significantly increased the number of CFU-GM colony compared with the control group. RG pre-treatment also ameliorated the histopathological damage in bone marrow, spleen, stomach and small intestine tissue.
Conclusions: These results demonstratethat Korean RG has preventive effects against 5-FU-induced myelotoxicity and gastrointestinal damage.
Methods: Rats (n = 50) were divided into five groups, nave, control (ip, 5-FU injection of 150 mg/kg), and RG pre-treatment (po, 25, 50 and 100 mg/kg for 5 days before 5-FU injection). On the 7th day after 5-FU injection, we evaluated the effects using peripheral hematological parameters, colony-forming assay, cytokine levels and histopathological finding.
Results: The peripheral white blood cell and the differential count were dramatically suppressed by 5-FU, while RG (50 and 100 mg/kg) treatment significantly improved total white blood cell, neutrophil, lymphocyte and platelet counts. Also, RG (100 mg/kg) pre-treatment significantly increased the number of CFU-GM colony compared with the control group. RG pre-treatment also ameliorated the histopathological damage in bone marrow, spleen, stomach and small intestine tissue.
Conclusions: These results demonstratethat Korean RG has preventive effects against 5-FU-induced myelotoxicity and gastrointestinal damage.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Griggs JJ / 1998 / Reducing the toxicity of anticancer therapy: new strategies / Leukemia Research 22 (1) : 27 ~ 33
2. [학술지(정기간행물)] - Kopecna L / 2001 / Late effects of anticancer therapy on kidney function in children with acute lymphoblastic leukemia / Bratisl Lek Listy 102 (8) : 357 ~ 360
3. [학술지(정기간행물)] - Gustafsson LL / 1996 / Cyclophosphamideinduced acute liver failure requiring transplantation in a patient with genetically deficient debrisoquine metabolism: a causal relationship? / Journal of Internal Medicine 240 (5) : 311 ~ 314
4. [보고서] - Fernandez-Ortega P / 2012 / Chemotherapy-induced nausea and vomiting in clinical practice: impact on patients' quality of life
5. [학술지(정기간행물)] - Grem JL / 2000 / 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development / Investigational New Drugs 18 (4) : 299 ~ 313
2. [학술지(정기간행물)] - Kopecna L / 2001 / Late effects of anticancer therapy on kidney function in children with acute lymphoblastic leukemia / Bratisl Lek Listy 102 (8) : 357 ~ 360
3. [학술지(정기간행물)] - Gustafsson LL / 1996 / Cyclophosphamideinduced acute liver failure requiring transplantation in a patient with genetically deficient debrisoquine metabolism: a causal relationship? / Journal of Internal Medicine 240 (5) : 311 ~ 314
4. [보고서] - Fernandez-Ortega P / 2012 / Chemotherapy-induced nausea and vomiting in clinical practice: impact on patients' quality of life
5. [학술지(정기간행물)] - Grem JL / 2000 / 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development / Investigational New Drugs 18 (4) : 299 ~ 313
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UCI(KEPA) : I410-ECN-0101-2014-519-000272865