지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.90 No.3
- 발행연도
- 2016.2
- 수록면
- 179 - 182 (4page)
이용수
초록· 키워드
오류제보하기
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
목차
INTRODUCTION
CASE REPORT
DISCUSSION
REFERENCES
참고문헌 (10)
참고문헌 신청
Mayer RJ. Moving beyond fluorouracil for colorectal cancer. N Engl J Med 2000;343: 963-4.
Porcello Marrone LC, Marrone BF, Pascoal TA, Schilling LP, Soder RB, Ferreira SS, et al. Posterior Reversible Encephalopathy Syndrome Associated with FOLFOX Chemotherapy. Case Rep Oncol Med 2013; 2013:306983.
Truman N, Nethercott D. Posterior reversible encephalopathy syndrome (PRES) after treatment with oxaliplatin and 5- fluorouracil. Clin Colorectal Cancer 2013; 12:70-2.
Chang YY, Lin JK, Jiang JK. Oxaliplatinrelated hyperammonaemic encephalopathy in a patient with colon cancer. Colorectal Dis 2012;14:e821.
Koenig H, Patel A. Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate. Arch Neurol 1970;23:155-60.
Porcello Marrone LC, Marrone BF, Pascoal TA, Schilling LP, Soder RB, Ferreira SS, et al. Posterior Reversible Encephalopathy Syndrome Associated with FOLFOX Chemotherapy. Case Rep Oncol Med 2013; 2013:306983.
Truman N, Nethercott D. Posterior reversible encephalopathy syndrome (PRES) after treatment with oxaliplatin and 5- fluorouracil. Clin Colorectal Cancer 2013; 12:70-2.
Chang YY, Lin JK, Jiang JK. Oxaliplatinrelated hyperammonaemic encephalopathy in a patient with colon cancer. Colorectal Dis 2012;14:e821.
Koenig H, Patel A. Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate. Arch Neurol 1970;23:155-60.
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UCI(KEPA) : I410-ECN-0101-2016-514-002640626