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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objectives：Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients.
Methods：The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS).
Results：There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls.
Conclusion：This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients. (J Korean Neuropsychiatr Assoc 2008;47(2):142-152)
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참고문헌 (25)
참고문헌 신청
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders. 4 ed / APA
Asberg M / 1997 / Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies / Ann N Y Acad Sci 836 : 158 ~ 181
Bellivier F / 1998 / Association between the tryptophan hydroxylase gene and manic- depressive illness / Arch Gen Psychiatry 55 : 33 ~ 37
Beskow J / 1976 / Determination of monoamine and monoamine metabolites in the human brain: post mortem studies in a group of suicides and in a control group / Acta Psychiatr
Craig SP / 1991 / Craig IW. Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3- p14 by in situ hybridization / Cytogenet Cell Genet 56 : 157 ~ 159
Asberg M / 1997 / Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies / Ann N Y Acad Sci 836 : 158 ~ 181
Bellivier F / 1998 / Association between the tryptophan hydroxylase gene and manic- depressive illness / Arch Gen Psychiatry 55 : 33 ~ 37
Beskow J / 1976 / Determination of monoamine and monoamine metabolites in the human brain: post mortem studies in a group of suicides and in a control group / Acta Psychiatr
Craig SP / 1991 / Craig IW. Localization of human tryptophan hydroxylase (TPH) to chromosome 11p15.3- p14 by in situ hybridization / Cytogenet Cell Genet 56 : 157 ~ 159
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