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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.12
- 수록면
- 407 - 411 (5page)
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Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthetic pathway of neurotransmitter serotonin. The serotonin system is functionally implicated in mood disorders and in learning and memory processes. In this report, we have generated four transgenic mouse founder lines by pronuclear injection of TPH eDNA, and have analyzed cellular and behavioral phenotype of these mice. Immunohistochemical analysis of the transgenic mouse brain stem demonstrated that there was no significant differences in TPH immunopositive neurons of TPH transgenic mice, compared to those of wild-type littermates. However, the TPH transgenic mice exhibited marked cognitive impairment as revealed by V-maze test experiment. The short-term memory of TPH transgenic was reduced by 72 % of wild-type mice, suggesting abnormal TPH gene dosage might have caused defect in spatial working memory processes. The reduction of alternation behavior in TPH transgenic mice was not attributed to the abnormal motor coordination, as confirmed by rotarod test. Thus, the findings suggest that serotonin homeostasis is involved in the control of short-term memory formation.
목차
Materials and Methods
Results
Discussion
Acknowledgment
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UCI(KEPA) : I410-ECN-0101-2009-510-016362621