지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제8권 제1호
- 발행연도
- 2010.1
- 수록면
- 38 - 44 (7page)
이용수
초록· 키워드
오류제보하기
Objective : We aimed to investigate the association between the tryptophan hydroxylase 2 (TPH2) G703T polymorphism and personality traits in a Korean population. The interaction between the TPH2 polymorphism and recent negative stressors in personality traits were also explored.
Methods：The TPH2 G703T polymorphism was genotyped in 369 community-dwelling Koreans (143 male, 226 female, 42.6±13.7years old). The Temperament and Character Inventory (TCI) was self-administered. Face-to-face interviews, investigating negative life stressors within the last 6 months, were also performed.
Results：There was no significant difference in TCI score among the three genotypes (93 G/G, 171 G/T, and 105 T/T subjects).
There was also no significant difference in TCI scores between subjects experiencing stressors and those without stressors.
However, there was a significant interaction between the TPH2 genotype and negative life stressors in the temperament of persistence (PS) (p=0.03); only subjects with the T/T genotype showed decreased PS with recent negative stressors.
Conclusion：We could not find a direct association between the TPH2 G703T polymorphism and personality traits. However,our findings suggest that the TPH2 G703T polymorphism might influence PS by interacting with a recent negative stress experience.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bouchard TJ Jr / 1994 / Genes, environment, and personality / Science 264 : 1700 ~ 1701
Brown SM / 2005 / A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity / Mol Psychiatry 10 : 884 ~ 888
Canli T / 2005 / Amygdala responsiveness is modulated by tryptophan hydroxylase- 2 gene variation / J Neural Transm 112 : 1479 ~ 1485
Cho MJ / 1993 / Diagnostic validity of the CES-D (Korean version) in the assessment of DSM-III-R major depression / J Korean Neuropsychiatr Assoc 32 : 381 ~ 399
Furmark T / 2008 / A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety / J Neurosci 28 : 13066 ~ 13074
Brown SM / 2005 / A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity / Mol Psychiatry 10 : 884 ~ 888
Canli T / 2005 / Amygdala responsiveness is modulated by tryptophan hydroxylase- 2 gene variation / J Neural Transm 112 : 1479 ~ 1485
Cho MJ / 1993 / Diagnostic validity of the CES-D (Korean version) in the assessment of DSM-III-R major depression / J Korean Neuropsychiatr Assoc 32 : 381 ~ 399
Furmark T / 2008 / A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety / J Neurosci 28 : 13066 ~ 13074
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