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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 189 - 195 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaTo determine if the maintenance effectiveness and tolerability of aripiprazole demonstrated in a 12-week study were maintained in an extension phase (up to 26 weeks).
MethodsaaThis study was the extension of our switching study from other antipsychotics to aripiprazole in symptomatically stable patients with schizophrenia or schizoaffective disorder. All the patients were randomly assigned to the aripiprazole group or the non-aripiprazole group. The effectiveness analysis consisted of the comparison of the upper bound of the 95% confidence interval (CI) of the mean Clinical Global Impression-Improvement (CGI-I) score to 4 (no change) at the end of the study.
ResultsaaAt the baseline, the aripiprazole group (n=135) and the non-aripiprazole group (n=31) were comparable with respect to their mean ages, gender distribution, baseline Positive and Negative Syndrome Scale scores, and Clinical Global Impression-Severity (CGI-S) scores. The study showed that the mean CGI-I score was 2.92 (95% CI: 2.72-3.12) in the aripiprazole group and 2.81 (95% CI: 2.35-3.26) in the non-aripiprazole group at 26 weeks. In the aripiprazole group, the remission rates at 12 and 26 weeks were 74.8% and 72.6%, respectively, and 80.2% of the patients with remission at 12 weeks maintained their remission state until the end of the study. About one-fourth of the patients in the aripiprazole group reported one or more spontaneous treatment-emergent adverse events, such as insomnia, headache, and nausea.
ConclusionaaThis study suggested that most clinically stable outpatients with schizophrenia maintain their remission states after being switched to aripiprazole, without serious symptom aggravation and adverse events over a course of 26 weeks.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Chrzanowski WK / 2006 / Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: a 52-week, open-label compa-rison
Findling RL / 2008 / A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia / Am J Psychia
Kane JM / 2002 / Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder / J Clin Psychiatry 63 : 763 ~
Kasper S / 2003 / haloperidol for long-term maintenance treatment following acute relapse of schizophrenia / Int J Neuropsychopharmacol 6 : 325 ~ 337
Kim CY / 2005 / Risperidone dos-ing pattern and clinical outcome in psychosis: an analysis of 1713 cases / J Clin Psychiatry 66 : 887 ~ 893
Findling RL / 2008 / A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia / Am J Psychia
Kane JM / 2002 / Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder / J Clin Psychiatry 63 : 763 ~
Kasper S / 2003 / haloperidol for long-term maintenance treatment following acute relapse of schizophrenia / Int J Neuropsychopharmacol 6 : 325 ~ 337
Kim CY / 2005 / Risperidone dos-ing pattern and clinical outcome in psychosis: an analysis of 1713 cases / J Clin Psychiatry 66 : 887 ~ 893
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