지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives：We compared the effect of aripiprazole, risperidone and quetiapine on the change of psychotic and motor symptoms during 4 weeks in Parkinson disease patients with psychotic feature after levodopa treatment.
Methods：Our study included both inpatients and outpatients. Of sixty patients, nineteen patients took risperidone, 21 patients took quetiapine and 20 patients took aripiprazole. Before administration of antipsychotic medications and 4weeks later, we evaluated psychotic symptoms and motor symptoms with Scale for the Assessment of Positive Symptoms(SAPS), Scale for the Assessment of Negative Symptoms(SANS) and motor part of Unified Parkinson’s Disease Rating Scale(UPDRS).
Results：After 4 weeks of antipsychotic treatments, the positive symptoms measured by SAPS showed group difference. In the post hoc test, risperidone group and aripiprazole group showed more improvement in positive symptoms scale than quetiapine. The change of motor symptoms measured by UPDRS showed group difference. In the post hoc test, the quetiapine group showed less aggravation in motor symptoms than the risperidone and the aripiprazole group. The aripiprazole group showed less aggravation in motor symptom than risperidone group, but there was no statistical significance.
Conclusion：Comparing the effectiveness of three antipsychotics(risperidone, quetiapine and aripiprazole) on the motor and psychotic symptoms in Parkinsonian patients who developed psychotic symptoms after taking levodopa, aripiprazole showed greater improvement in positive symptoms than quetiapine and similar effect with risperidone.
Methods：Our study included both inpatients and outpatients. Of sixty patients, nineteen patients took risperidone, 21 patients took quetiapine and 20 patients took aripiprazole. Before administration of antipsychotic medications and 4weeks later, we evaluated psychotic symptoms and motor symptoms with Scale for the Assessment of Positive Symptoms(SAPS), Scale for the Assessment of Negative Symptoms(SANS) and motor part of Unified Parkinson’s Disease Rating Scale(UPDRS).
Results：After 4 weeks of antipsychotic treatments, the positive symptoms measured by SAPS showed group difference. In the post hoc test, risperidone group and aripiprazole group showed more improvement in positive symptoms scale than quetiapine. The change of motor symptoms measured by UPDRS showed group difference. In the post hoc test, the quetiapine group showed less aggravation in motor symptoms than the risperidone and the aripiprazole group. The aripiprazole group showed less aggravation in motor symptom than risperidone group, but there was no statistical significance.
Conclusion：Comparing the effectiveness of three antipsychotics(risperidone, quetiapine and aripiprazole) on the motor and psychotic symptoms in Parkinsonian patients who developed psychotic symptoms after taking levodopa, aripiprazole showed greater improvement in positive symptoms than quetiapine and similar effect with risperidone.
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UCI(KEPA) : I410-ECN-0101-2009-513-018620416