지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 511 - 517 (7page)
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초록· 키워드
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Background/Aims: There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk. Methods: A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea. Serum CRP level was compared between high-risk and low-risk adenoma groups and independent predictors of high-risk adenoma were analyzed using multivariate regression analysis. Results: Among the 3,309 eligible patients, the high-risk adenoma group had higher serum CRP levels than the low-risk adenoma group (P=0.000). In addition, patients with a high-risk adenoma were more frequently included in the high CRP group than in the low CRP group (8.6% vs. 4.0%, P<0.001). The prevalence of high-risk adenoma was 3.5 times higher in the highest quartile of CRP level (P=0.000) compared with that in the lowest quartile. In logistic regression analysis, a higher quartile CRP level was found to be an independent risk factor for high-risk adenoma (odds ratio, 1.8; 95% confidence interval, 1.3–2.5; P=0.000). Conclusions: High CRP level is associated with high-risk adenoma in both men and women. Our data may support the association between chronic inflammation and colorectal neoplasia, which warrants further investigation.
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참고문헌 (39)
참고문헌 신청
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Winawer SJ / 1993 / Prevention of colorectal cancer by colonoscopic polypectomy: the National Polyp Study Workgroup / N Engl J Med 329:1977~1981
Itzkowitz SH / 2004 / Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation / Am J Physiol Gastrointest Liver Physiol 287:G7~G17
Jemal A / 2010 / Cancer statistics, 2010 / CA Cancer J Clin 60:277~300
Burt RW. / 2010 / Colorectal cancer screening / Curr Opin Gastroenterol 26:466~470
Winawer SJ / 1993 / Prevention of colorectal cancer by colonoscopic polypectomy: the National Polyp Study Workgroup / N Engl J Med 329:1977~1981
Itzkowitz SH / 2004 / Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation / Am J Physiol Gastrointest Liver Physiol 287:G7~G17
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