지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.10
- 수록면
- 259 - 268 (10page)
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초록· 키워드
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Objectives：Chronic alcohol ingestion is associated with structural alterations in the brain. In patients with alcohol dependence, thalamic volume is frequently diminished, commensurate with the amount of alcohol consumption, duration of illness, and cognitive impairment. Since the thalamus is composed of histologically and functionally distinct nuclei, we aimed to investigate volumetric changes of these nuclei in patients with alcohol dependence.
Methods：Twenty-three participants with alcohol dependence who had abstained from drinking for at least 3 months (alcohol group) and 21 age-matched healthy controls (control group) underwent 3T magnetic resonance imaging. The volumes of 50 individual thalamic nuclei were reconstructed using FreeSurfer 6.0.0. We compared normalized volumes of thalamic nuclei between the two groups using analysis of covariance, controlling for age. The p-values were corrected using False Discovery Rate (p<0.05).
Results：The alcohol group demonstrated atrophy of the whole thalamus and nuclei in the anterior, ventral, intralaminar, and medial thalamus. However, the volumes of bilateral lateral geniculate, medial geniculate, suprageniculatelimitans, pulvinar lateral, and right pulvinar inferior nuclei which are included in posterior thalamus, were not significantly different between the two groups.
Conclusion：In the alcohol group, atrophy of most thalamic nuclei which are associated with language processing, visuospatial memory, autobiographical memory, executive function and attention were not normalized after 3 months of sobriety. Furthermore, thalamic nuclei volumes, which are associated with visual and auditory information processing, were not significantly different compared to controls. We suggest that this could be microstructural evidence of relatively preserved visual attention and auditory startle response in patients with alcohol dependence.
Methods：Twenty-three participants with alcohol dependence who had abstained from drinking for at least 3 months (alcohol group) and 21 age-matched healthy controls (control group) underwent 3T magnetic resonance imaging. The volumes of 50 individual thalamic nuclei were reconstructed using FreeSurfer 6.0.0. We compared normalized volumes of thalamic nuclei between the two groups using analysis of covariance, controlling for age. The p-values were corrected using False Discovery Rate (p<0.05).
Results：The alcohol group demonstrated atrophy of the whole thalamus and nuclei in the anterior, ventral, intralaminar, and medial thalamus. However, the volumes of bilateral lateral geniculate, medial geniculate, suprageniculatelimitans, pulvinar lateral, and right pulvinar inferior nuclei which are included in posterior thalamus, were not significantly different between the two groups.
Conclusion：In the alcohol group, atrophy of most thalamic nuclei which are associated with language processing, visuospatial memory, autobiographical memory, executive function and attention were not normalized after 3 months of sobriety. Furthermore, thalamic nuclei volumes, which are associated with visual and auditory information processing, were not significantly different compared to controls. We suggest that this could be microstructural evidence of relatively preserved visual attention and auditory startle response in patients with alcohol dependence.
목차
서론
대상 및 방법
결과
고찰
참고문헌
참고문헌 (60)
참고문헌 신청
Sherman SM / 2016 / Thalamus plays a central role in ongoing cortical functioning / Nat Neurosci 19:533~541
Varela C / 2014 / Thalamic neuromodulation and its implications for executive networks / Front Neural Circuit 8:69
Philp DJ / 2014 / Thalamic volume and thalamo-cortical white matter tracts correlate with motor and verbal memory performance / Neuroimage 91:77~83
Schmahmann JD / 2008 / Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems / Cortex 44:1037~1066
Behrens TEJ / 2003 / Noninvasive mapping of connections between human thalamus and cortex using diffusion imaging / Nat Neurosci 6:750~757
Varela C / 2014 / Thalamic neuromodulation and its implications for executive networks / Front Neural Circuit 8:69
Philp DJ / 2014 / Thalamic volume and thalamo-cortical white matter tracts correlate with motor and verbal memory performance / Neuroimage 91:77~83
Schmahmann JD / 2008 / Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems / Cortex 44:1037~1066
Behrens TEJ / 2003 / Noninvasive mapping of connections between human thalamus and cortex using diffusion imaging / Nat Neurosci 6:750~757
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