지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 360 - 367 (8page)
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초록· 키워드
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Objective: The aim of this study was to investigate ziprasidone plasma concentration, daily dose and clinical efficacy and safety in Han Chinese and Mongolian patients with first-episode schizophrenia.
Methods: A total of 123 inpatients affected by schizophrenia were recruited from the Mental Health Center of Inner Mongolia in China. Ziprasidone plasma concentration, clinical efficacy and side effects were systematically evaluated at baseline, and at 1, 2, 4, and 6 weeks. Metabolic measures such as changes in weight, body mass index (BMI), fasting blood glucose (FBG), triglycerides, and cholesterol, were also recorded.
Results: 90 patients completed the study. Compared with Han patients, on average, Mongolian patients received a significantly higher ziprasidone dosage for adequate symptom control during the 6-week period and had a lower plasma concentration-to-dose ratio. The Mongolian patients also experienced greater increases in weight and BMI. No significant differences between the two ethnic groups were found in the rate of reduction in the Positive and Negative Syndrome Scale (PANSS) score, Treatment Emergent Symptom Scale (TESS) total score, FBG, triglycerides, cholesterol or Q-Tc interval.
Conclusion: Compared to Han Chinese patients, Mongolian patients appeared to have increased ziprasidone clearance and require higher doses to achieve effective treatment for schizophrenia.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Kay SR / 1987 / The positive and negative syndrome scale(PANSS)for schizophrenia / Schizophr Bull 13:261~276
Guy W / 1976 / ECDEU Assessment Manual for Psychopharmacology / US Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Psychopharmacology Research Branch, Division of Extramural Research Programs
Wilner K / 2000 / The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid / Br J Clin Pharmacol 49(Suppl):57S~60S
Obach RS / 2012 / Reduction and methylation of ziprasidone by glutathione, aldehyde oxidase, and thiol s-methyltransferase in humans: an in vitro study / Xenobiotica 42:1049~1057
Beedham C / 2003 / Ziprasidone metabolism, aldehyde oxidase, and clinical implications / J Clin Psychopharmacol 23:229~232
Guy W / 1976 / ECDEU Assessment Manual for Psychopharmacology / US Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute of Mental Health, Psychopharmacology Research Branch, Division of Extramural Research Programs
Wilner K / 2000 / The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid / Br J Clin Pharmacol 49(Suppl):57S~60S
Obach RS / 2012 / Reduction and methylation of ziprasidone by glutathione, aldehyde oxidase, and thiol s-methyltransferase in humans: an in vitro study / Xenobiotica 42:1049~1057
Beedham C / 2003 / Ziprasidone metabolism, aldehyde oxidase, and clinical implications / J Clin Psychopharmacol 23:229~232
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