지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 339 - 344 (6page)
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초록· 키워드
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Background and Purpose The magnetic resonance imaging in multiple sclerosis (MAGNIMS) group recently proposed guidelines to replace the existing dissemination-in-space criteria in McDonald 2010 magnetic resonance imaging (MRI) criteria for diagnosing multiple sclerosis. There has been insufficient research regarding their applicability in Asians. Objective of this study was to determine the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of McDonald 2010 and MAGNIMS 2016 MRI criteria with the aim of verifying their applicability in Sri Lankan patients. Methods Patients with clinically isolated syndrome diagnosed by consultant neurologists were recruited from five major neurology centers. Baseline and follow-up MRI scans were performed within 3 months from the initial presentation and at one year after baseline MRI, respectively. McDonald 2010 and MAGNIMS 2016 MRI criteria were applied to all MRI scans. Patients were followed-up for 2 years to assess the conversion to clinically definite multiple sclerosis (CDMS). The sensitivity, specificity, accuracy, PPV, and NPV for predicting the conversion to CDMS were calculated. Results Forty-two of 66 patients converted to CDMS. Thirty-seven fulfilled the McDonald 2010 MRI criteria, and 33 converted to CDMS. MAGNIMS 2016 MRI criteria were fulfilled by 29, with 28 converting to CDMS. The sensitivity, specificity, accuracy, PPV, and NPV were 78%, 83%, 64%, 89%, and 69%, respectively, for the McDonald 2010 criteria, and 67%, 96%, 77%, 96%, and 62% for the MAGNIMS 2016 MRI criteria. Conclusions MAGNIMS 2016 MRI criteria were superior to McDonald 2010 MRI criteria in specificity, accuracy, and PPV, but inferior in sensitivity and NPV.
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참고문헌 (22)
참고문헌 신청
Brownlee WJ / 2017 / Diagnosis of multiple sclerosis: progress and challenges / Lancet 389:1336~1346
Piccolo L / 2015 / Multiple sclerosis in Japan appears to be a milder disease compared to the UK / J Neurol 262:831~836
Gamage SMK / 2018 / Multiple sclerosis patients with markedly low intrathecal antibody response in Sri Lanka / Mult Scler Int 2018:5342936
Singhal B / 2015 / Multiple sclerosis-Indian perspective / Neurol India 63:824~825
Li T / 2014 / Multiple sclerosis: clinical features and MRI findings in Northern China / Eur J Med Res 19:20
Piccolo L / 2015 / Multiple sclerosis in Japan appears to be a milder disease compared to the UK / J Neurol 262:831~836
Gamage SMK / 2018 / Multiple sclerosis patients with markedly low intrathecal antibody response in Sri Lanka / Mult Scler Int 2018:5342936
Singhal B / 2015 / Multiple sclerosis-Indian perspective / Neurol India 63:824~825
Li T / 2014 / Multiple sclerosis: clinical features and MRI findings in Northern China / Eur J Med Res 19:20
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