지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 15 - 20 (6page)
이용수
초록· 키워드
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Background and Purpose Recent studies have shown that several nonmotor symptoms differ between Parkinson’s disease (PD) and drug-induced parkinsonism (DIP). However, there have been no reports on cardiovascular autonomic function in DIP, and so this study investigated whether cardiovascular autonomic function differs between PD and DIP patients.
Methods This study consecutively enrolled 20 DIP patients, 99 drug-naïve PD patients, and 25 age-matched healthy controls who underwent head-up tilt-table testing and 24-h ambulatory blood pressure monitoring.
Results Orthostatic hypotension was more frequent in patients with PD or DIP than in healthy controls. In DIP, orthostatic hypotension was associated with the underlying psychiatric diseases and neuroleptics use, whereas prokinetics were not related to orthostatic hypotension. The supine blood pressure, nighttime blood pressure, and nocturnal blood pressure dipping did not differ significantly between the DIP and control groups. Supine hypertension and nocturnal hypertension were more frequent in PD patients than in controls.
Conclusions The included DIP patients frequently exhibited orthostatic hypotension that was associated with the underlying diseases as well as the nature of and exposure time to the offending drugs. Clinicians should individualize the manifestations of DIP according to underlying diseases as well as the action mechanism of and exposure time to each offending drug.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Brigo F / 2014 / Differentiating drug-induced parkinsonism from Parkinson’s disease: an update on non-motor symptoms and investigations / Parkinsonism Relat Disord 20 : 808
Broadley AJ / 2005 / Baroreflex sensitivity is reduced in depression / Psychosom Med 67 : 648 ~ 651
Dauphinot V / 2012 / Depressive symptoms and autonomic nervous system dysfunction in an elderly population-based study: the PROOF study / J Affect Disord 143 : 153 ~ 159
Freeman R / 2011 / Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome / Clin Auton Res 21 : 69
Gibb WR / 1988 / The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease / J Neurol Neurosurg Psychiatry 51 : 745 ~ 752
Broadley AJ / 2005 / Baroreflex sensitivity is reduced in depression / Psychosom Med 67 : 648 ~ 651
Dauphinot V / 2012 / Depressive symptoms and autonomic nervous system dysfunction in an elderly population-based study: the PROOF study / J Affect Disord 143 : 153 ~ 159
Freeman R / 2011 / Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome / Clin Auton Res 21 : 69
Gibb WR / 1988 / The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease / J Neurol Neurosurg Psychiatry 51 : 745 ~ 752
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