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논문 기본 정보

자료유형
학술저널
저자정보
Suh Wool (Department of Ophthalmology Institute of Ophthalmology and Optometry Ewha Womans University Mok-Dong Hospital Ewha Womans University School of Medicine Seoul Korea.) Baek Sung Uk (Department of Ophthalmology Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Korea.) Oh Jungsu S. (Department of Nuclear Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Seo Seung Yeon (Department of Nuclear Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Kim Jae Seung (Department of Nuclear Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Han You Mie (Department of Nuclear Medicine Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong Korea.) Kim Min Seung (Department of Neurology Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong Korea.) Kang Suk Yun (Department of Neurology Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.11
발행연도
2023.3
수록면
1 - 9 (9page)
DOI
10.3346/jkms.2023.38.e86

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Background: Drug-induced parkinsonism (DIP) is common, but diagnosis is challenging. Although dopamine transporter imaging is useful, the cost and inconvenience are problematic, and an easily accessible screening technique is needed. We aimed to determine whether optical coherence tomography (OCT) findings could differentiate DIP from Parkinson’s disease (PD). Methods: We investigated 97 de novo PD patients and 27 DIP patients using OCT and [18F] N-(3-fluoropropyl)-2b-carbon ethoxy-3b-(4-iodophenyl) nortropane (FP-CIT) positron emission tomography. We compared peripapillary retinal nerve fiber layer thickness (pRNFLT) and macular retinal thickness (mRT) between PD and DIP patients as well as interocular differences in the pRNFLT and the mRT. Asymmetric index (%) for retinal thickness (AIRT) was calculated to measure the interocular differences between pRNFLT and mRT. The correlation between AIRT and total striatal specific/non-specific binding ratio asymmetry index (SNBRAI) was investigated in PD and DIP patients. Results: No significant differences in pRNFLT and mRT values were observed between PD and DIP patients (all P values > 0.090). The mean SNBRAI was significantly higher in PD than in DIP (P = 0.008) patients; however, AIRT did not differ between PD and DIP patients in pRNFLT and mRT (all P values > 0.100). SNBRAI did not correlate with AIRT of pRNFL or mRT in PD and DIP patients (all P values > 0.060). Conclusion: Our study showed no benefit of retinal thickness and interocular asymmetry measurements using OCT for distinguishing PD from DIP in the early stages. Additional investigations are needed for confirmation.

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