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자료유형
학술저널
저자정보
저널정보
대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제11권 제3호
발행연도
2015.1
수록면
220 - 226 (7page)

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Orthostatic hypotension (OH) occurs when mechanisms for the regulation of orthostatic BP control fails. Such regulation depends on the barorefexes, normal blood volume, and defenses against excessive venous pooling. OH is common in the elderly and is associated with an increase in mortality rate. Tere are many causes of OH. Aging coupled with diseases such as diabetes and Parkinson’s disease results in a prevalence of 10–30% in the elderly. Tese conditions cause barorefex failure with resulting combination of OH, supine hypertension, and loss of diurnal variation of BP. Te treatment of OH is imperfect since it is impossible to normalize standing BP without generating excessive supine hypertension. Te practical goal is to improve standing BP so as to minimize symptoms and to improve standing time in order to be able to undertake orthostatic activities of daily living, without excessive supine hypertension. It is possible to achieve these goals with a combination of fudrocortisone, a pressor agent (midodrine or droxidopa), supplemented with procedures to improve orthostatic defenses during periods of increased orthostatic stress. Such procedures include water bolus treatment and physical countermaneuvers. We provide a pragmatic guide on patient education and the patient-orientated approach to the moment to moment management of OH.

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