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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 17 - 22 (6page)
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Background and Purpose: We investigated the relationship between the β-fibrinogen gene (FGB) -455 G/A
polymorphism and plasma fibrinogen levels in Korean ischemic stroke patients. We also determined whether the
frequency of the -455 G/A polymorphism differed between two subtypes of noncardioembolic stroke: large-artery
atherosclerosis (LAA) and small-vessel occlusion (SVO).
Methods: A total of 267 patients with noncardioembolic stroke were enrolled. Plasma fibrinogen and other risk
factors for stroke were evaluated. FGB -455 G/A genotypes were determined by polymerase chain reaction with
restrictive enzyme Hae III and automatic DNA sequencing.
Results: The FGB -455 G/A polymorphism was significantly associated with an elevated plasma fibrinogen level
(p<0.001). The frequency of the A allele in Korean stroke patients was 16.7%. However, the frequency of the -455
G/A polymorphism did not differ between LAA and SVO.
Conclusions: The plasma fibrinogen level might be affected by the -455 G/A polymorphism in noncardioembolic
stroke patients. However, the LAA and SVO subtypes of ischemic stroke were not affected by the -455 G/A
polymorphism.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
[
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treat
Danesh J / 1998 / Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies / JAMA 279 : 14
Di Napoli M / 2001 / Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke / Stroke 32 : 133 ~ 138
Doggen CJ / 2000 / Fibrinogen polymorphisms are not associated with the risk of myocardial infarction / Br J Haematol 110 : 935 ~ 938
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treat
Danesh J / 1998 / Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies / JAMA 279 : 14
Di Napoli M / 2001 / Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke / Stroke 32 : 133 ~ 138
Doggen CJ / 2000 / Fibrinogen polymorphisms are not associated with the risk of myocardial infarction / Br J Haematol 110 : 935 ~ 938
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