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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Department of Neurology, Hallym University College of Medicine
Background : Leptin is a protein product of the ob gene which is expressed exclusively in adipose tissue cells. The aims of this study are to determine whether leptin level independently or in combination with other risk factors affects the onset of ischemic stroke and to determine the related subtypes of ischemic stroke. Methods : 109 patients with first-ever ischemic stroke and age-sex frequency matched 65 controls were included. Subtypes of ischemic stroke were classified by Trial of ORG 10172 in Acute Stroke Treatment (TOAST). Systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), smoking, diabetes mellitus, and hypertension were recorded. Blood samples were obtained within 24 hours of the onset. Triglyceride (TG), total cholesterol (Tchol), high-density lipoprotein cholesterol (HDL-c), low-density ipoprotein cholesterol (LDL-c), apolipoprotein A-1 (apol A-1), apolipoprotein B (apol B), fibrinogen, fasting blood sugar(FBS), and leptin were analyzed. Results : Patients with ischemic stroke had a higher rate of diabetes mellitus and ypertension than those in the control group. Furthermore, SBP, DBP, BMI, T-chol, LDL-c, Apo B, FBS, and the level of leptin in stroke victims were higher as well. In bivariate correlations between variables, high levels of leptin were associated with high BMI. High leptin levels and hypertension were significant risk factors for ischemic stroke in multivariate regression analysis. In each subtype analysis, high plasma leptin remained independent risk factor for large artery atherosclerosis (LAA) and small vessel occlusion (SVO). Conclusions : Elevated level of leptin may be an important link in the development of LAA and SVO.
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