지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: Smoking is a major risk factor of stroke, but not all smokers develop stroke. This individual difference could be explained by the variation of detoxification capacity. We investigated the relationship of smoking with the genetic polymorphism of a detoxification enzyme (glutathione S-transferase: GST). Methods: This study was conducted as a case-control study.
Conventional risk factors for stroke and 3 genetic polymorphisms of GST (GSTM1, GSTT1 , and GSTP1 ) were studied in both 290 acute ischemic stroke patients and 290 age and sex matched controls. Smoking status was determined by urinary cotinine level. The effect of interaction of GST polymorphisms and smoking on stroke risk was investigated. Results: Stroke patients had higher cotinine level compared to that of control (P <0.01). There was little difference between the patient group and control group with regard to the GST polymorphism alone, but significant interaction was noticed between the GST polymorphism and the smoking status. When we stratified the group according to the smoking status by cotinine level, stroke was significantly more frequent in GSTM1 null type and GSTT1, GSTP1 wild type of the high cotinine level group (OR and 95% CI: 2.115,1.219-3.670; 2.620, 1.480-4.638; 2.212, 1.343-3.644 respectively). Conclusion: GST polymorphisms interact with the smoking and confer an increased risk of ischemic stroke, indicating that genetic polymorphism of GST might reveal smokers who are more susceptible to the ischemic stroke.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Ambrose JA / 2004 / The pathophysiology of cigarette smoking and cardiovascular disease: An update / J Am Coll Cardiol 43 : 1731 ~ 1737
Apseloff G / 1994 / The importance of measuring cotinine levels to identify smokers in clinical trials / Clin Pharmacol Ther 56 : 460 ~ 462
Dusinska M / 2001 / Glutathione s-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans / Mutat Res 482 : 47 ~ 55
Girisha KM / 2004 / T1 and m1 polymorphism in glutathione s-transferase gene and coronary artery disease in north indian population / Indian J Med Sci 58 : 520 ~ 526
Gore JM / 1984 / Validity of serum total cholesterol level obtained within 24 hours of acute myocardial infarction / Am J Cardiol 54 : 722 ~ 725
Apseloff G / 1994 / The importance of measuring cotinine levels to identify smokers in clinical trials / Clin Pharmacol Ther 56 : 460 ~ 462
Dusinska M / 2001 / Glutathione s-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans / Mutat Res 482 : 47 ~ 55
Girisha KM / 2004 / T1 and m1 polymorphism in glutathione s-transferase gene and coronary artery disease in north indian population / Indian J Med Sci 58 : 520 ~ 526
Gore JM / 1984 / Validity of serum total cholesterol level obtained within 24 hours of acute myocardial infarction / Am J Cardiol 54 : 722 ~ 725
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