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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.12
- 수록면
- 275 - 282 (8page)
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This study was carried out to investigate the effect of fibrinogen genotype and other characteristics on the plasma fibrinogen levels. Many studies have confirmed that high plasma fibrinogen levels are associated with the increased risk of ischaemic heart disease, stroke and arterial disease. And fibrinogen levels are related with age, obesity, cholesterol and alcohol consumption, genotypes. For this study the blood samples were collected from 93 healthy Koreans (66 males and 27 females). The blood samples were individually analyzed by smoking status, cholesterol levels, genotype, age, and gender. The plasma fibrinogen was assayed by clotting method (modified Clauss assay) and cholesterol was assayed by cholesterol oxidase method. Subjects were classified by current smokers, ex-smokers (＜6 month), or nonsmokers. The β-fibrinogen genotype was detected by PCR of relevant region and digestion with HaeⅢ, with the H₁H₁ allele allowing cleavage by this restriction enzyme and H₂H₂ allele being refractory. In conclusion, the study shows that the factor of the increasement in the fibrinogen level was closely related with the cholesterol level, smoking status and genotype (H₁H₂); but there was no significant difference by gender. Especially, among the people over 50 years of age, fibrinogen level was higher with the increasement of cholesterol level (＜200 ㎎/㎗), current smoker, and genotype H₁H₂.
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UCI(KEPA) : I410-ECN-0101-2009-510-017340861