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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제5호
- 발행연도
- 2015.1
- 수록면
- 370 - 374 (5page)
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초록· 키워드
오류제보하기
Pulmonary hemorrhage as the initial manifestation of systemic lupus erythematosus (SLE) has been rarely reported in children. We present the case of a 10-year-old girl who was admitted to Kangbuk Samsung Hospital with hemoptysis. She had a 5-day history of cough with dyspnea. On physical exam, breath sound was significantly decreased combined with rales on both lung fields. Blood tests revealed pancytopenia, decreased complement levels (C3, 21.28 mg/dL; C4, 3.10 mg/dL), positive antinuclear antibody (>1:640) and anti–double-stranded DNA antibody (262.5 IU/mL). Chest computed tomography revealed patchy ground glass opacity on both lung fields. She had proteinuria and diffuse lupus nephritis (International Society of Nephrology/Renal Pathology Society class IV-G(A)) confirmed by renal biopsy. High-dose methylprednisolone pulse therapy (30 mg/kg/day) was given for 3 days and then switched to a maintenance dose (1 mg/kg/day). Initially hemoptysis resolved after administration of methylprednisolone, but recurred on the 14th day of treatment. She was then treated with cyclophosphamide pulse therapy and hemoptysis subsided without recurrence. She was discharged on the 31st day of admission. She continued to receive monthly cyclophosphamide pulse therapy until the occurrence of leukopenia and then her regimen was switched to mycophenolate and hydroxychloroquine. SLE continues to be well controlled after 18 months of treatment. Recognition of pulmonary hemorrhage as a possible initial manifestation of SLE is crucial for early diagnosis. SLE was successfully treated with good outcome.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Austin HA 3rd / 1986 / Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs / N Engl J Med 314 : 614 ~ 619
Bader-Meunier B / 2005 / Initial presentation of childhood-onset systemic lupus erythematosus : a French multicenter study / J Pediatr 146 : 648 ~ 653
Bagga A / 2003 / Mycophenolate mofetil and prednisolone therapy in children with steroid-dependent nephrotic syndrome / Am J Kidney Dis 42 : 1114 ~ 1120
Belmont HM / 1996 / Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium / Arthritis R
Bertsias GK / 2012 / Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association(EULAR/ERA-EDTA)recommendations for
Bader-Meunier B / 2005 / Initial presentation of childhood-onset systemic lupus erythematosus : a French multicenter study / J Pediatr 146 : 648 ~ 653
Bagga A / 2003 / Mycophenolate mofetil and prednisolone therapy in children with steroid-dependent nephrotic syndrome / Am J Kidney Dis 42 : 1114 ~ 1120
Belmont HM / 1996 / Pathology and pathogenesis of vascular injury in systemic lupus erythematosus. Interactions of inflammatory cells and activated endothelium / Arthritis R
Bertsias GK / 2012 / Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association(EULAR/ERA-EDTA)recommendations for
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